粪便微生物群移植治疗复发性艰难梭菌感染、溃疡性结肠炎和克罗恩病患者的有效性:一项系统评价
Effectiveness of Fecal Microbiota Transplantation Treatment in Patients With Recurrent Clostridium difficile Infection, Ulcerative Colitis, and Crohn's Disease: A Systematic Review.
作者信息
Jaramillo Arturo P, Awosusi Babatope L, Ayyub Javaria, Dabhi Karan Nareshbhai, Gohil Namra V, Tanveer Nida, Hussein Sally, Pingili Shravya, Makkena Vijaya Krishna
机构信息
General Practice, California Institute of Behavioral Neurosciences & Psychology, California, USA.
Pathology and Laboratory Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
出版信息
Cureus. 2023 Jul 19;15(7):e42120. doi: 10.7759/cureus.42120. eCollection 2023 Jul.
Cronh's disease and ulcerative colitis (UC) are diseases with unknown etiologies that cause ongoing inflammation in the gastrointestinal system. Chron's disease causes immunological dysregulation, and UC causes intestinal harm due to immune reactions. According to our study, fecal microbiota transplantation (FMT) has many benefits in the treatment of inflammatory bowel disease (IBD) by restoring intestinal homeostasis and reducing clinical symptoms. In mildly symptomatic patients with UC, an FMT treatment combined with an anti-inflammatory diet can produce remission, which would then be followed by a diet that maintained the anti-inflammatory effects. The efficacy of FMT consists of preventing flares or the consequences of IBD. As a result, we must emphasize that more investigation should be done before developing a therapeutic procedure for FMT in IBD and its associated consequences.
克罗恩病和溃疡性结肠炎(UC)是病因不明的疾病,可导致胃肠道系统持续炎症。克罗恩病会引起免疫调节失调,而UC则因免疫反应导致肠道损伤。根据我们的研究,粪便微生物群移植(FMT)通过恢复肠道内稳态和减轻临床症状,在治疗炎症性肠病(IBD)方面有诸多益处。在轻度症状的UC患者中,FMT治疗联合抗炎饮食可产生缓解,随后采用维持抗炎效果的饮食。FMT的疗效包括预防IBD发作或其后果。因此,我们必须强调,在开发针对IBD及其相关后果的FMT治疗程序之前,应进行更多研究。