Mondal Arijit, Nayak Amit Kumar, Chakraborty Prithviraj, Banerjee Sabyasachi, Nandy Bankim Chandra
Department of Pharmaceutical Chemistry, M.R. College of Pharmaceutical Sciences and Research, Balisha 743 234, India.
Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar 751 003, India.
Pharmaceutics. 2023 Jul 31;15(8):2064. doi: 10.3390/pharmaceutics15082064.
Cancer is one of the most common lethal diseases and the leading cause of mortality worldwide. Effective cancer treatment is a global problem, and subsequent advancements in nanomedicine are useful as substitute management for anti-cancer agents. Nanotechnology, which is gaining popularity, enables fast-expanding delivery methods in science for curing diseases in a site-specific approach, utilizing natural bioactive substances because several studies have established that natural plant-based bioactive compounds can improve the effectiveness of chemotherapy. Bioactive, in combination with nanotechnology, is an exceptionally alluring and recent development in the fight against cancer. Along with their nutritional advantages, natural bioactive chemicals may be used as chemotherapeutic medications to manage cancer. Alginate, starch, xanthan gum, pectin, guar gum, hyaluronic acid, gelatin, albumin, collagen, cellulose, chitosan, and other biopolymers have been employed successfully in the delivery of medicinal products to particular sites. Due to their biodegradability, natural polymeric nanobiocomposites have garnered much interest in developing novel anti-cancer drug delivery methods. There are several techniques to create biopolymer-based nanoparticle systems. However, these systems must be created in an affordable and environmentally sustainable way to be more readily available, selective, and less hazardous to increase treatment effectiveness. Thus, an extensive comprehension of the various facets and recent developments in natural polymeric nanobiocomposites utilized to deliver anti-cancer drugs is imperative. The present article provides an overview of the latest research and developments in natural polymeric nanobiocomposites, particularly emphasizing their applications in the controlled and targeted delivery of anti-cancer drugs.
癌症是最常见的致命疾病之一，也是全球主要的死亡原因。有效的癌症治疗是一个全球性问题，而纳米医学的后续进展可用作抗癌药物的替代管理方法。日益流行的纳米技术能够以位点特异性方法在科学领域实现快速扩展的给药方式，利用天然生物活性物质，因为多项研究已证实，天然植物来源的生物活性化合物可提高化疗效果。生物活性与纳米技术相结合，是抗癌斗争中一项格外诱人的最新进展。除了其营养优势外，天然生物活性化学物质可用作化疗药物来治疗癌症。藻酸盐、淀粉、黄原胶、果胶、瓜尔胶、透明质酸、明胶、白蛋白、胶原蛋白、纤维素、壳聚糖和其他生物聚合物已成功用于将药物输送到特定部位。由于其可生物降解性，天然聚合物纳米生物复合材料在开发新型抗癌药物递送方法方面引起了广泛关注。有几种技术可用于创建基于生物聚合物的纳米颗粒系统。然而，这些系统必须以经济且环境可持续的方式创建，以便更易于获得、更具选择性且危害更小，从而提高治疗效果。因此，深入了解用于递送抗癌药物的天然聚合物纳米生物复合材料的各个方面和最新进展至关重要。本文概述了天然聚合物纳米生物复合材料的最新研究和进展，特别强调了它们在抗癌药物的控释和靶向递送中的应用。
