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（密尔）I. I. 约翰斯顿和（雅克）卡斯提取物的植物化学成分比较、非靶向代谢组学分析及其体外生物细胞毒性和抗增殖活性

Comparison of Phytochemical Composition and Untargeted Metabolomic Analysis of an Extract from (Mill.) I. I. Johnst and (Jacq.) Cass. and Biological Cytotoxic and Antiproliferative Activity In Vitro.

作者信息

Vargas-Madriz Ángel Félix, Luzardo-Ocampo Ivan, Moreno-Celis Ulisses, Roldán-Padrón Octavio, Chávez-Servín Jorge Luis, Vergara-Castañeda Haydé A, Martínez-Pacheco Mónica, Mejía Carmen, García-Gasca Teresa, Kuri-García Aarón

机构信息

Department of Cell and Molecular Biology, School of Natural Sciences, Universidad Autonoma de Queretaro, Querétaro 76230, Mexico.

Tecnologico de Monterrey, The Institute for Obesity Research, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64849, Mexico.

出版信息

Plants (Basel). 2023 May 15;12(10):1987. doi: 10.3390/plants12101987.

DOI:10.3390/plants12101987
PMID:37653904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10222540/
Abstract

(CA) and (PR) are representative edible plants that are a traditional food source in Mexico. This research aimed to analyze the phytochemical composition and untargeted metabolomics analysis of CA and PR and evaluate their antiproliferative effect in vitro. The phytochemical composition (UPLC-DAD-QToF/MS-ESI) identified up to 38 polyphenols and selected organic acids that were clustered by the untargeted metabolomics in functional activities linked to indolizidines, pyridines, and organic acids. Compared with PR, CA displayed a higher reduction in the metabolic activity of human SW480 colon adenocarcinoma cells (LC: 10.65 mg/mL), and both extracts increased the total apoptotic cells and arrested cell cycle at G0/G1 phase. PR increased mRNA gene expression, whereas both extracts reduced mRNA expression. Rutin/epigallocatechin gallate displayed the highest affinity to APC and K-RAS proteins in silico. Further research is needed to experiment on other cell lines. Results suggested that CA and PR are polyphenol-rich plant sources exhibiting antiproliferative effects in vitro.

摘要

仙人掌（CA）和仙人果（PR）是墨西哥传统食物来源中的代表性可食用植物。本研究旨在分析仙人掌和仙人果的植物化学成分及非靶向代谢组学，并评估它们在体外的抗增殖作用。植物化学成分（超高效液相色谱-二极管阵列-四极杆飞行时间质谱联用仪-电喷雾电离质谱，UPLC-DAD-QToF/MS-ESI）鉴定出多达38种多酚和选定的有机酸，这些物质通过非靶向代谢组学在与吲哚里西啶、吡啶和有机酸相关的功能活性中聚类。与仙人果相比，仙人掌对人SW480结肠腺癌细胞的代谢活性降低幅度更大（半数致死浓度：10.65 mg/mL），且两种提取物均增加了总凋亡细胞数量，并使细胞周期停滞在G0/G1期。仙人果增加了mRNA基因表达，而两种提取物均降低了mRNA表达。芦丁/表没食子儿茶素没食子酸酯在计算机模拟中对APC和K-RAS蛋白表现出最高亲和力。还需要对其他细胞系进行进一步研究。结果表明，仙人掌和仙人果是富含多酚的植物来源，在体外具有抗增殖作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/61c3396d94da/plants-12-01987-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/056121b8e1cf/plants-12-01987-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/3360ea6db1a3/plants-12-01987-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/8199df8bb7ce/plants-12-01987-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/111709dea6a7/plants-12-01987-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/61c3396d94da/plants-12-01987-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/056121b8e1cf/plants-12-01987-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/3360ea6db1a3/plants-12-01987-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/8199df8bb7ce/plants-12-01987-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/111709dea6a7/plants-12-01987-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/10222540/61c3396d94da/plants-12-01987-g005.jpg

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