Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.
The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China.
Medicine (Baltimore). 2023 Sep 8;102(36):e34911. doi: 10.1097/MD.0000000000034911.
Helicobacter pylori (H pylori) is a common pathogen, and about 50% of the world population have been infected with it, so the infection of H pylori has been an urgent public health problem worldwide. H pylori has evolved a variety of strategies to help itself colonize, adapt to the environment and proliferate. Cholesterol glucoside (CG), a characteristic substance in H pylori, is related to the membrane stability, morphology, inflammation induction and immune evasion of H pylori. Therefore, CG may be a new target to weaken the infection effect of H pylori. The biosynthesis process, structure and biological function of CG specific to H pylori, as well as anti-CG drugs are discussed and analyzed in this review, in order to explore whether the inhibition of CG synthesis can be an effective strategy to eradicate H pylori.
幽门螺杆菌（H pylori）是一种常见的病原体，约有 50%的世界人口受到感染，因此 H pylori 的感染已成为全球范围内亟待解决的公共卫生问题。H pylori 已经进化出多种策略来帮助其定植、适应环境和增殖。胆固醇糖苷（CG）是 H pylori 的特征物质，与 H pylori 的膜稳定性、形态、炎症诱导和免疫逃避有关。因此，CG 可能是一个削弱 H pylori 感染效果的新靶点。本文综述了 H pylori 特异性 CG 的生物合成过程、结构和生物学功能，以及抗 CG 药物，以探讨抑制 CG 合成是否可以成为根除 H pylori 的有效策略。
