糖尿病易感基因胰岛素样生长因子2信使核糖核酸结合蛋白2的多态性与弥漫性大B细胞淋巴瘤风险之间的关联。
Association Between Polymorphism in Diabetes Susceptibility Gene Insulin-Like Growth Factor 2mRNA-Binding Protein 2 and Risk of Diffuse Large B-Cell Lymphoma.
作者信息
Zhou Weiling, Gao Qian, He Cuiying, Wang Lianjing, Wang Yuan, Feng Lei, Li Weijing, Liu Wei, Ma Ruijuan, Liu Lihong
机构信息
Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
出版信息
Clin Med Insights Oncol. 2023 Oct 9;17:11795549231201128. doi: 10.1177/11795549231201128. eCollection 2023.
BACKGROUND
Numerous studies have shown that polymorphisms in the diabetes susceptibility gene, insulin-like growth factor 2mRNA-binding protein 2 (IGF2BP2), are associated with the occurrence and development of various malignant tumors; however, their correlation with the onset of diffuse large B-cell lymphoma (DLBCL) is still unknown. Therefore, this study aimed to explore whether IGF2BP2 polymorphisms increase the risk of developing DLBCL.
METHODS
This study included 295 DLBCL patients and 331 healthy individuals. Peripheral blood was collected, and polymerase chain reaction-ligase detection reaction (PCR-LDR) was used to detect gene polymorphisms. Logistic regression was used to assess the association between IGF2BP2 polymorphism and the risk of DLBCL, adjusted for age, sex, and body mass index (BMI). < .05 indicated statistical significance.
RESULTS
The rs4402960 polymorphism in the gene was associated with the occurrence and development of DLBCL. After adjusting for age, sex, and BMI, GT (odd ratio [OR] = 1.54; 95% confidence interval [CI] = 1.08-2.19; = .016), TT (OR = 2.00; 95% CI = 1.09-3.68; = .026), and T genotype carrying (GT + TT) (OR = 1.62; 95% CI = 1.17-2.25; = .004) significantly increased the risk of DLBCL. This study also found that the polymorphism rs1470579 was related to the development of DLBCL. After adjusting for age, sex, and BMI, AC (OR = 1.55; 95% CI = 1.11-2.17; = .010), CC (OR = 2.18; 95% CI = 1.17-4.06; = .014), and C genotype carrying (AC + CC) (OR = 1.64; 95% CI = 1.19-2.26; = .002) significantly increased the risk of DLBCL.
CONCLUSIONS
Our study found that polymorphism in the gene was associated with an increased risk of developing DLBCL.
背景
大量研究表明，糖尿病易感基因胰岛素样生长因子2信使核糖核酸结合蛋白2（IGF2BP2）的多态性与多种恶性肿瘤的发生发展相关；然而，其与弥漫性大B细胞淋巴瘤（DLBCL）发病的相关性仍不清楚。因此，本研究旨在探讨IGF2BP2多态性是否会增加患DLBCL的风险。
方法
本研究纳入了295例DLBCL患者和331名健康个体。采集外周血，采用聚合酶链反应-连接酶检测反应（PCR-LDR）检测基因多态性。采用逻辑回归分析评估IGF2BP2多态性与DLBCL风险之间的关联，并对年龄、性别和体重指数（BMI）进行校正。P < 0.05表示具有统计学意义。
结果
该基因中的rs4402960多态性与DLBCL的发生发展相关。在对年龄、性别和BMI进行校正后，GT（比值比[OR]=1.54；95%置信区间[CI]=1.08-2.19；P = 0.016）、TT（OR = 2.00；95% CI = 1.09-3.68；P = 0.026）以及携带T基因型（GT+TT）（OR = 1.62；95% CI = 1.17-2.25；P = 0.004）显著增加了患DLBCL的风险。本研究还发现，rs1470579多态性与DLBCL的发展相关。在对年龄、性别和BMI进行校正后，AC（OR = 1.55；95% CI = 1.11-2.17；P = 0.010）、CC（OR = 2.18；95% CI = 1.17-4.06；P = 0.014）以及携带C基因型（AC+CC）（OR = 1.64；95% CI = 1.19-2.26；P = 0.002）显著增加了患DLBCL的风险。
结论
我们的研究发现，该基因的多态性与患DLBCL风险的增加相关。
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