微生物感染作为肺癌的潜在风险因素：探究人乳头瘤病毒和肺炎衣原体的作用

Microbial infections as potential risk factors for lung cancer: Investigating the role of human papillomavirus and chlamydia pneumoniae.

作者信息

Drokow Emmanuel Kwateng, Effah Clement Yaw, Agboyibor Clement, Budu Jemima Twumwaah, Arboh Francisca, Kyei-Baffour Priscilla Akyaa, Xiao Yao, Zhang Fan, Wu Irene Xy

机构信息

Hunan Provinical Key Laboratory of Clinical Epidemiology, Central South University, Changsha 410083, Hunan, China.

Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha 410083, Hunan, China.

出版信息

AIMS Public Health. 2023 Aug 3;10(3):627-646. doi: 10.3934/publichealth.2023044. eCollection 2023.

DOI:10.3934/publichealth.2023044

PMID:37842273

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10567973/

Abstract

BACKGROUND

Lung cancer is the leading cause of cancer morbidity and mortality worldwide. Apart from tobacco smoke and dietary factors, microbial infections have been reported as the third leading cause of cancers globally. Deciphering the association between microbiome and lung cancer will provide potential biomarkers and novel insight in lung cancer progression. In this current study, we performed a meta-analysis to decipher the possible association between and human papillomavirus (HPV) and the risk of lung cancer.

METHODS

Literature search was conducted in most English and Chinese databases. Data were analyzed using CMA v.3.0 and RevMan v.5.3 software (Cochrane-Mantel-Haenszel method) by random-effects (DerSimonian and Laird) model.

RESULTS

The overall pooled estimates for HPV studies revealed that HPV infections in patients with lung cancer were significantly higher than those in the control group ( = 2.33, 95% = 1.57-3.37, < 0.001). Base on subgroup analysis, HPV infection rate was significantly higher in Asians ( = 6.38, 95% = 2.33-17.46, < 0.001), in tissues ( = 5.04, 95% = 2.27-11.19, < 0.001) and blood samples ( = 1.40, 95% = 1.02-1.93, = 0.04) of lung cancer patients but non-significantly lower in males ( = 0.84, 95% = 0.57-1.22, =0.35) and among lung cancer patients at clinical stage I-II ( = 0.95, 95% = 0.61-1.49, = 0.82). The overall pooled estimates from studies revealed that infection is a risk factor among lung cancer patients who are IgA seropositive ( = 1.88, 95% = 1.30-2.70, < 0.001) and IgG seropositive ( = 1.50, 95% = 1.10-2.04, = 0.010). All seronegative IgA ( = 0.69, 95% = 0.42-1.16, = 0.16) and IgG ( = 0.66, 95% = 0.42-105, = 0.08) titers are not associative risk factors to lung cancer.

CONCLUSIONS

Immunoglobulin (IgA) and IgG seropositive titers of and lungs infected with HPV types 16 and 18 are potential risk factors associated with lung cancer.

摘要

背景

肺癌是全球癌症发病率和死亡率的主要原因。除了烟草烟雾和饮食因素外，微生物感染据报道是全球癌症的第三大主要原因。解读微生物群与肺癌之间的关联将为肺癌进展提供潜在的生物标志物和新的见解。在本研究中，我们进行了一项荟萃分析，以解读[此处原文缺失某种微生物]与人类乳头瘤病毒（HPV）和肺癌风险之间的可能关联。

方法

在大多数英文和中文数据库中进行文献检索。使用CMA v.3.0和RevMan v.5.3软件（Cochrane-Mantel-Haenszel方法）通过随机效应（DerSimonian和Laird）模型分析数据。

结果

HPV研究的总体合并估计显示，肺癌患者中的HPV感染显著高于对照组（比值比=2.33，95%置信区间=1.57 - 3.37，P<0.001）。基于亚组分析，亚洲人（比值比=6.38，95%置信区间=2.33 - 17.46，P<0.001）、肺癌患者的组织（比值比=5.04，95%置信区间=2.27 - 11.19，P<0.001）和血液样本（比值比=1.40，95%置信区间=1.02 - 1.93，P = 0.04）中的HPV感染率显著更高，但男性（比值比=0.84，95%置信区间=0.57 - 1.22，P = 0.35）以及临床I-II期肺癌患者（比值比=0.95，95%置信区间=0.61 - 1.49，P = 0.82）中的感染率无显著降低。[此处原文缺失某种微生物]研究的总体合并估计显示，[某种微生物]感染是IgA血清阳性（比值比=1.88，95%置信区间=1.30 - 2.70，P<0.001）和IgG血清阳性（比值比=1.50，95%置信区间=1.10 - 2.04，P = 0.010）肺癌患者的一个风险因素。所有IgA血清阴性（比值比=0.69，95%置信区间=0.42 - 1.16，P = 0.16）和IgG血清阴性（比值比=0.66，95%置信区间=0.42 - 1.05，P = 0.08）滴度不是肺癌的相关风险因素。