日本胃肠道长期新冠症状患者的临床特征。
Clinical features of Japanese patients with gastrointestinal long-COVID symptoms.
作者信息
Yagi Kazuma, Asakura Takanori, Terai Hideki, Ohgino Keiko, Masaki Katsunori, Namkoong Ho, Chubachi Shotaro, Miyata Jun, Kawada Ichiro, Kodama Nobuhiro, Sakamoto Satoshi, Umeda Akira, Ishiguro Takashi, Ishii Makoto, Fukunaga Koichi
机构信息
Division of Pulmonary Medicine, Department of Medicine Keio University School of Medicine Tokyo Japan.
Department of Clinical Medicine (Laboratory of Bioregulatory Medicine) Kitasato University School of Pharmacy Tokyo Japan.
出版信息
JGH Open. 2023 Dec 6;7(12):998-1002. doi: 10.1002/jgh3.13006. eCollection 2023 Dec.
Gastrointestinal (GI) long-COVID symptoms, including diarrhea and abdominal pain, have been reported in patients with long-COVID. However, the clinical features of patients with GI long-COVID symptoms remain unclear. We conducted a large-scale prospective cohort study focusing on the clinical characteristics of patients with GI long-COVID symptoms in Japan. Among 943 COVID-19 patients, 58 patients (6.2%) had GI long-COVID symptoms. The health-related quality of life (QOL) parameters (the Short Form-8 [SF-8] and Euro Quality of Life 5 Dimensions 5 level [EQ-5D-5L]) at 12 months after diagnosis in patients with GI long-COVID symptoms were significantly lower than in those without GI long-COVID symptoms ( < 0.0001). Moreover, patients with GI long-COVID symptoms had more varied long-COVID symptoms compared to patients without GI long-COVID symptoms.
新冠后长期症状患者中已报告出现胃肠道（GI）长期症状，包括腹泻和腹痛。然而，有胃肠道长期症状患者的临床特征仍不明确。我们在日本开展了一项大规模前瞻性队列研究，重点关注有胃肠道长期症状患者的临床特征。在943例新冠患者中，58例（6.2%）有胃肠道长期症状。有胃肠道长期症状患者在诊断后12个月时的健康相关生活质量（QOL）参数（简短健康调查问卷8项版[SF - 8]和欧洲五维度健康量表5级版[EQ - 5D - 5L]）显著低于无胃肠道长期症状的患者（<0.0001）。此外，与无胃肠道长期症状的患者相比，有胃肠道长期症状的患者出现的新冠后长期症状更多样化。
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