利用磷脂膜获得生物记忆的物理洞察力。

Physical insights into biological memory using phospholipid membranes.

机构信息

Department of Physics and Astronomy, University of Tennessee, Knoxville, TN, 37996, USA.

Shull Wollan Center, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.

出版信息

Eur Phys J E Soft Matter. 2024 Jan 11;47(1):2. doi: 10.1140/epje/s10189-023-00391-7.

Abstract

Electrical signals may propagate along neuronal membranes in the brain, thus enabling communication between nerve cells. In doing so, lipid bilayers, fundamental scaffolds of all cell membranes, deform and restructure in response to such electrical activity. These changes impact the electromechanical properties of the membrane, which then physically store biological memory. This memory can exist either over a short or long period of time. Traditionally, biological memory is defined by the strengthening or weakening of transmissions between individual neurons. Here, we show that electrical stimulation may also alter the properties of the lipid membrane, thus pointing toward a novel mechanism for memory storage. Furthermore, based on the analysis of existing electrophysiological data, we study molecular mechanisms underlying the long-term potentiation in phospholipid membranes. Finally, we examine possible relationships between the memory capacitive properties of lipid membranes, neuronal learning, and memory.

摘要

电信号可以沿着大脑神经元细胞膜传播,从而实现神经细胞之间的通讯。在这个过程中,作为所有细胞膜基本支架的脂双层会响应这种电活动而发生变形和重构。这些变化会影响膜的机电特性,从而物理上存储生物记忆。这种记忆可以在短时间或长时间内存在。传统上,生物记忆是通过单个神经元之间的传输的增强或减弱来定义的。在这里,我们表明电刺激也可以改变脂质膜的性质,从而为记忆存储提供一种新的机制。此外,我们基于对现有电生理数据的分析,研究了磷脂膜中长时程增强的分子机制。最后,我们研究了脂质膜的记忆电容特性、神经元学习和记忆之间的可能关系。

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