埃及女性乳腺癌患者循环髓源性抑制细胞及其亚群的表型分析：一项单中心病例对照研究。
Phenotypic Analysis of Circulating Myeloid Derived Suppressor Cells and Their Subpopulations in Egyptian Females with Breast Cancer: A Single-Centre Case-Control Study.
机构信息
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.
Department of General Surgery, Faculty of Medicine, Cairo University, Egypt.
出版信息
Asian Pac J Cancer Prev. 2024 Jan 1;25(1):257-263. doi: 10.31557/APJCP.2024.25.1.257.
BACKGROUND
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with suppressive function that has been thoroughly documented in the setting of cancer. Our purpose was to evaluate levels of MDSC and their subsets in a cohort of Egyptian patients with breast cancer.
METHODS
Evaluation of peripheral blood total MDSC and its subset was done using multicolor flowcytometry in 30 malignant, 10 benign breast tumor patients and 10 healthy control females.
RESULTS
BC patients had higher total MDSC levels compared to controls (p= 0.01) particularly the Monocytic MDSC (M-MDSC) and abnormal MDSC subsets (p = 0.001 and p <0.001, respectively). A tumor size > 2 cm exhibited significantly higher granulocytic MDSCs (G-MDSCs) compared to tumor size < 2 cm (p= 0.02) whereas abnormal MDSCs were significantly higher in patients with a tumor size < 2 cm (p = 0.037).
CONCLUSION
MDSC and its subsets can be used as a prognostic marker of tumor size as well as a potential targets for treatment in breast cancer patients.
背景
髓源性抑制细胞（MDSC）是具有抑制功能的未成熟髓系细胞，其在癌症环境中的作用已得到充分证实。我们的目的是评估一组埃及乳腺癌患者中 MDSC 及其亚群的水平。
方法
通过多色流式细胞术评估 30 名恶性、10 名良性乳腺肿瘤患者和 10 名健康女性对照者外周血总 MDSC 及其亚群。
结果
与对照组相比，BC 患者的总 MDSC 水平更高（p=0.01），尤其是单核细胞来源的 MDSC（M-MDSC）和异常 MDSC 亚群（p=0.001 和 p<0.001）。肿瘤大小>2cm 的患者粒细胞 MDSC（G-MDSC）显著高于肿瘤大小<2cm 的患者（p=0.02），而肿瘤大小<2cm 的患者异常 MDSC 显著更高（p=0.037）。
结论
MDSC 及其亚群可作为肿瘤大小的预后标志物，也是乳腺癌患者治疗的潜在靶点。
Zotero 插件