Pan Mengting, Zhao Yurui, Qiao Jinjuan, Meng Xiangying
School of Medical Laboratory, Weifang Medical University, Weifang, 261053, Shandong, China.
Folia Microbiol (Praha). 2024 Apr;69(2):283-304. doi: 10.1007/s12223-024-01144-5. Epub 2024 Feb 17.
The worldwide spread of pathogenic microorganisms poses a significant risk to human health. Electrochemical biosensors have emerged as dependable analytical tools for the point-of-care detection of pathogens and can effectively compensate for the limitations of conventional techniques. Real-time analysis, high throughput, portability, and rapidity make them pioneering tools for on-site detection of pathogens. Herein, this work comprehensively reviews the recent advances in electrochemical biosensors for pathogen detection, focusing on those based on the classification of recognition elements, and summarizes their principles, current challenges, and prospects. This review was conducted by a systematic search of PubMed and Web of Science databases to obtain relevant literature and construct a basic framework. A total of 171 publications were included after online screening and data extraction to obtain information of the research advances in electrochemical biosensors for pathogen detection. According to the findings, the research of electrochemical biosensors in pathogen detection has been increasing yearly in the past 3 years, which has a broad development prospect, but most of the biosensors have performance or economic limitations and are still in the primary stage. Therefore, significant research and funding are required to fuel the rapid development of electrochemical biosensors. The overview comprehensively evaluates the recent advances in different types of electrochemical biosensors utilized in pathogen detection, with a view to providing insights into future research directions in biosensors.
致病微生物在全球范围内的传播对人类健康构成了重大风险。电化学生物传感器已成为用于病原体即时检测的可靠分析工具，能够有效弥补传统技术的局限性。实时分析、高通量、便携性和快速性使其成为病原体现场检测的开创性工具。在此，本文全面综述了用于病原体检测的电化学生物传感器的最新进展，重点关注基于识别元件分类的传感器，并总结了其原理、当前面临的挑战和前景。本综述通过系统检索PubMed和Web of Science数据库以获取相关文献并构建基本框架。经过在线筛选和数据提取，共纳入171篇出版物，以获取用于病原体检测的电化学生物传感器研究进展的信息。研究结果表明，在过去3年中，电化学生物传感器在病原体检测方面的研究逐年增加，具有广阔的发展前景，但大多数生物传感器存在性能或经济方面的局限性，仍处于初级阶段。因此，需要大量的研究和资金投入来推动电化学生物传感器的快速发展。本综述全面评估了用于病原体检测的不同类型电化学生物传感器的最新进展，以期为生物传感器未来的研究方向提供见解。
