鼻窦错构瘤与慢性喉水肿导致严重呼吸困难
Sinonasal Hamartoma and Chronic Laryngeal Edema Causing Severe Dyspnea.
作者信息
Gavric Jelena, Valjarevic Svetlana, Jovanovic Milan B, Miladinovic Nenad
机构信息
Department of Otorhinolaryngology with Maxillofacial surgery, Clinical Hospital Center "Zemun", Belgrade, 11000 Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
出版信息
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):1302-1306. doi: 10.1007/s12070-023-04276-1. Epub 2023 Oct 21.
BACKGROUND
Sinonasal hamartomas, according to the 5th edition of the World Health Organisation classification of head and neck tumours are divided into respiratory epithelial adenomatoid hamartoma (REAH), seromucinous hamartoma and chondromesenchymal hamartoma. Seromucinous hamartoma are benign proliferations of small eosinophilic glands surrounded by fibrous stroma and cuboidal cells. Hamartomas of the nasal cavity and paranasal sinuses are rare entities, clinically presenting as sinonasal polyposis.
CASE PRESENTATION
A 79- year-old female patient was referred to our emergency room due to severe dyspnea. Anterior rhinoscopy revealed unilateral greyish polypoid mass obstructing the middle, inferior and common nasal meatus. Systemic corticosteroids and oxygen therapy were administered under observation. Computerized tomographic imaging of the paranasal sinuses with contrast on all three planes showed an opacified polypoid mass in all meatus and the maxillary, anterior ethmoidal and sphenoidal sinus posteriorly extending to the choanae. On the coronal plane a widening of the olfactory clefts about 12 mm was described. FESS visualized that the polypoid mass originated from the posterior septum and extended to all meatus anteriorly and to the choanae posteriorly. The polypoid lesion was endoscopically completely excised. Histopathological analysis revealed a seromucinous hamartoma.
CONCLUSION
Seromucinous hamartoma are rare benign tumors of the sinonasal region with potential of malignant alteration. Unfortunately, they share symptoms and clinical appearance with other benign conditions of the sinonasal region. Therefore, it is even more important to consider them as a differential diagnose.
背景
根据世界卫生组织头颈部肿瘤分类第5版,鼻窦错构瘤分为呼吸上皮性腺瘤样错构瘤(REAH)、浆液黏液性错构瘤和软骨间叶性错构瘤。浆液黏液性错构瘤是由纤维性间质和立方体细胞包绕的小嗜酸性腺体的良性增生。鼻腔和鼻窦错构瘤是罕见的病变,临床上表现为鼻息肉病。
病例介绍
一名79岁女性患者因严重呼吸困难被转诊至我们的急诊室。前鼻镜检查发现单侧灰白色息肉样肿物阻塞中鼻道、下鼻道和总鼻道。在观察下给予全身糖皮质激素和氧疗。鼻窦的计算机断层扫描成像在所有三个平面上增强扫描显示所有鼻道内有一个不透明的息肉样肿物,上颌窦、前筛窦和蝶窦肿物向后延伸至后鼻孔。在冠状面上,嗅裂增宽约12毫米。功能性鼻内镜鼻窦手术显示息肉样肿物起源于后鼻中隔,向前延伸至所有鼻道,向后延伸至后鼻孔。息肉样病变经内镜完全切除。组织病理学分析显示为浆液黏液性错构瘤。
结论
浆液黏液性错构瘤是鼻窦区域罕见的良性肿瘤,有恶变的可能。不幸的是,它们与鼻窦区域的其他良性疾病有共同的症状和临床表现。因此,将它们作为鉴别诊断更为重要。