采用联合全身免疫炎症指数和预后营养指数预测局部晚期鼻咽癌重度放射性口腔黏膜炎。
Prediction of severe radiation-induced oral mucositis in locally advanced nasopharyngeal carcinoma using the combined systemic immune-inflammatory index and prognostic nutritional index.
机构信息
Department of Radiation Oncology, the First Affiliated Hospital of Guangxi Medical University, 22# Shuangyong Road, Nanning, 530021, Guangxi, China.
Oncology Department, Nanchong Central Hospital, The Second Clinical Institute of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
出版信息
Eur Arch Otorhinolaryngol. 2024 May;281(5):2627-2635. doi: 10.1007/s00405-024-08536-w. Epub 2024 Mar 12.
OBJECTIVE
Severe radiation-induced oral mucositis (sRIOM) can seriously affect patients' quality of life and treatment compliance. This study was to investigate the utility of the systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) in predicting sRIOM in patients with locally advanced nasopharyngeal carcinoma (LANPC).
METHODS
295 patients with LANPC were retrospectively screened. The pre-radiotherapy SII and PNI were calculated based on peripheral blood samples. A receiver operating characteristic (ROC) curve was used to determine the cut-off value. Logistic regression was used for univariate and multivariate analyses. Patients were classified into three groups based on the SII-PNI score: score of 2, high SII (> cut-off value) and low PNI (≤ cut-off value); score of 1, either high SII or low PNI; score of 0, neither high SII nor low PNI.
RESULTS
The SII-PNI demonstrated significant predictive ability for sRIOM occurrence, as evidenced by an area under the curve (AUC) of 0.738. The incidence rates of sRIOM with SII-PNI score of 2, 1, and 0 were 73.86%, 44.35%, and 18.07%, respectively. Multivariate analysis confirmed that the SII-PNI score was an independent risk factor for sRIOM.
CONCLUSION
The SII-PNI score is a reliable and convenient indicator for predicting sRIOM in patients with LANPC.
目的
严重放射性口腔黏膜炎（sRIOM）可严重影响患者的生活质量和治疗依从性。本研究旨在探讨全身免疫炎症指数（SII）和预后营养指数（PNI）在预测局部晚期鼻咽癌（LANPC）患者 sRIOM 中的作用。
方法
回顾性筛选 295 例 LANPC 患者。根据外周血样本计算放疗前 SII 和 PNI。采用受试者工作特征（ROC）曲线确定截断值。采用单因素和多因素logistic 回归分析。根据 SII-PNI 评分将患者分为三组：评分 2，高 SII（>截断值）和低 PNI（≤截断值）；评分 1，高 SII 或低 PNI；评分 0，既无高 SII 也无低 PNI。
结果
SII-PNI 对 sRIOM 发生具有显著预测能力，曲线下面积（AUC）为 0.738。SII-PNI 评分 2、1 和 0 的 sRIOM 发生率分别为 73.86%、44.35%和 18.07%。多因素分析证实 SII-PNI 评分是 sRIOM 的独立危险因素。
结论
SII-PNI 评分是预测 LANPC 患者 sRIOM 的可靠、简便指标。
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