Ma Ke, Cheng Zhixiang, Jiang Hao, Lin Zhangya, Liu Chuansheng, Liu Xianguo, Lu Lijuan, Lu Yan, Tao Wei, Wang Suoliang, Yang Xiaoqiu, Yi Qishan, Zhang Xiaomei, Zhang Ying, Liu Yanqing
Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Department of Algology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
J Pain Res. 2024 Mar 8;17:953-963. doi: 10.2147/JPR.S445171. eCollection 2024.
Ion channel drugs have been increasing used for chronic pain management with progress in the development of selective calcium channel modulators. Although ion channel drugs have been proven safe and effective in clinical practice, uncertainty remains regarding its use to treat chronic pain. To standardize the clinical practice of ion channel drug for the treatment of chronic pain, the National Health Commission Capacity Building and Continuing Education Center for Pain Diagnosis and Treatment Special Ability Training Project established an expert group to form an expert consensus on the use of ion channel drugs for the treatment of chronic pain after repeated discussions on existing medical evidence combined with the well clinical experience of experts. The consensus provided information on the mechanism of action of ion channel drugs and their recommendations, caution use, contraindications, and precautions for their use in special populations to support doctors in their clinical decision-making.
随着选择性钙通道调节剂的发展，离子通道药物在慢性疼痛管理中的应用日益增加。尽管离子通道药物在临床实践中已被证明安全有效，但在其用于治疗慢性疼痛方面仍存在不确定性。为规范离子通道药物治疗慢性疼痛的临床实践，国家卫生健康委能力建设和继续教育中心疼痛诊疗专项能力培训项目成立了专家组，在结合专家丰富临床经验对现有医学证据进行反复讨论后，就离子通道药物治疗慢性疼痛的使用形成专家共识。该共识提供了离子通道药物的作用机制信息及其推荐意见、谨慎使用情况、禁忌证以及在特殊人群中使用的注意事项，以支持医生进行临床决策。
