Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Level 2, Clinical Research Centre, Bock MD11, 10 Medical Drive, Singapore, 117597, Singapore.
National University Health System, Singapore, Singapore.
Breast Cancer Res Treat. 2024 Jun;205(3):425-438. doi: 10.1007/s10549-023-07216-3. Epub 2024 Mar 16.
Depression is one of the main psychological responses experienced by patients with breast cancer perioperatively. Therefore, this review aimed to synthesize the prevalence rate of depression preoperatively among patients with breast cancer.
Six databases were searched for published articles, which recruited female patients aged 18 years and above, diagnosed with breast cancer and planned for breast surgery. Grey literatures were searched from ProQuest Theses and Dissertations, Science.gov and CogPrints. Studies published in English from the inception of databases to January 2023 were considered. Two reviewers screened, extracted, and appraised the data independently. Joanna Briggs Institute data collection form was used for data collection. Hoy's Risk of Bias Tool was utilized to assess the individual study's quality. Review Manager 5.4 software was utilized for meta-analysis. Subgroup analyses were conducted to explore the reasons for any heterogeneity. Publication bias was evaluated by Egger's test and funnel plot.
Twenty studies involving 32,143 patients with breast cancer were included. Meta-analyses revealed an overall preoperative prevalence of 30% among all studies. Subgroup analyses showed that studies conducted in the Middle East and North Africa used purposive sampling, with patients undergoing mastectomy and lumpectomy and with moderate risk of bias reported higher prevalence of preoperative depression (54%, 44%, 40%, and 49%, respectively) as compared to other respective subgroups.
The high prevalence of preoperative depression among women with breast cancer indicated the need for health care professionals to provide more psychological support to them.
抑郁是乳腺癌患者围手术期主要的心理反应之一。因此，本综述旨在综合术前乳腺癌患者抑郁的患病率。
在六个数据库中搜索发表的文章，这些文章招募了年龄在 18 岁及以上、被诊断患有乳腺癌并计划接受乳房手术的女性患者。从 ProQuest 论文和学位论文、Science.gov 和 CogPrints 中搜索灰色文献。考虑了从数据库开始到 2023 年 1 月发表的英文研究。两名评审员独立筛选、提取和评估数据。使用 Joanna Briggs 研究所数据收集表进行数据收集。使用 Hoy 的偏倚风险工具评估个体研究的质量。使用 Review Manager 5.4 软件进行荟萃分析。进行亚组分析以探讨任何异质性的原因。通过 Egger 检验和漏斗图评估发表偏倚。
共有 20 项涉及 32143 例乳腺癌患者的研究被纳入。荟萃分析显示，所有研究的总体术前患病率为 30%。亚组分析表明，在中东和北非进行的研究采用了目的性抽样，接受乳房切除术和肿块切除术且偏倚风险为中度的研究报告术前抑郁的患病率较高（分别为 54%、44%、40%和 49%），而其他各自的亚组的患病率则较低。
乳腺癌患者术前抑郁的高患病率表明，医疗保健专业人员需要为她们提供更多的心理支持。
