运动强度控制患有乳腺癌的小鼠的肿瘤生长。

Exercise intensity governs tumor control in mice with breast cancer.

机构信息

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States.

出版信息

Front Immunol. 2024 Mar 1;15:1339232. doi: 10.3389/fimmu.2024.1339232. eCollection 2024.

DOI:10.3389/fimmu.2024.1339232

PMID:38495879

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10940460/

Abstract

INTRODUCTION

Exercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity.

METHODS

We subjected mice to low intensity (Li), moderate intensity (Mi) or high intensity (Hi) exercise, or untrained control (Co) groups based on their individual maximal running capacity.

RESULTS

We found that exercise intensity played a critical role in tumor control. Only Mi exercise delayed tumor growth and reduced tumor burden, whereas Li or Hi exercise failed to exert similar antitumor effects. While both Li and Mi exercise normalized the tumor vasculature, only Mi exercise increased tumor infiltrated CD8+ T cells, that also displayed enhanced effector function (higher proliferation and expression of CD69, INFγ, GzmB). Moreover, exercise induced an intensity-dependent mobilization of CD8+ T cells into the bloodstream.

CONCLUSION

These findings shed light on the intricate relationship between exercise intensity and cancer, with implications for personalized and optimal exercise prescriptions for tumor control.

摘要

简介

运动被推荐作为癌症的辅助治疗方法，但效果因人而异。我们的假设是，这种效果取决于运动强度。

方法

我们根据个体的最大跑步能力，将小鼠分为低强度（Li）、中强度（Mi）或高强度（Hi）运动组或未经训练的对照组（Co）。

结果

我们发现运动强度在肿瘤控制中起着关键作用。只有 Mi 运动能够延缓肿瘤生长并降低肿瘤负担，而 Li 或 Hi 运动则未能产生类似的抗肿瘤效果。虽然 Li 和 Mi 运动都使肿瘤血管正常化，但只有 Mi 运动增加了浸润肿瘤的 CD8+T 细胞，这些细胞还表现出增强的效应功能（更高的增殖和 CD69、INFγ、GzmB 的表达）。此外，运动诱导了 CD8+T 细胞向血液中进行强度依赖性的动员。