Duivenvoorden Wilhelmina C M, Margel David, Subramony Gayathri Vishal, Duceppe Emmanuelle, Yousef Sadiya, Naeim Magda, Khajehei Mohammad, Hopmans Sarah, Popovic Snezana, Ber Yaara, Heels-Ansdell Diane, Devereaux Philip J, Pinthus Jehonathan H
Department of Surgery, Division of Urology, Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada.
Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.
JACC Basic Transl Sci. 2023 Dec 20;9(3):364-379. doi: 10.1016/j.jacbts.2023.10.010. eCollection 2024 Mar.
Low testosterone (T), common in aging men, associates with cardiovascular disease. We investigated whether follicle-stimulating hormone (FSH), which is affected by T, modulates the cardiovascular effects associated with low T or castration. FSHβ:low-density lipoprotein receptor (LDLR) mice, untreated or castrated (orchiectomy, gonadotropin-releasing hormone agonist or antagonist), demonstrated significantly less atherogenesis compared with similarly treated LDLR mice, but not following FSH delivery. Smaller plaque burden in LDLR mice receiving gonadotropin-releasing hormone antagonists vs agonists were nullified in FSHβ:LDLR mice. Atherosclerotic and necrotic plaque size and macrophage infiltration correlated with serum FSH/T. In patients with prostate cancer, FSH/T following androgen-deprivation therapy initiation predicted cardiovascular events. FSH facilitates cardiovascular disease when T is low or eliminated.
低睾酮（T）在老年男性中很常见，与心血管疾病有关。我们研究了受T影响的促卵泡激素（FSH）是否调节与低T或去势相关的心血管效应。未处理或去势（睾丸切除术、促性腺激素释放激素激动剂或拮抗剂）的FSHβ：低密度脂蛋白受体（LDLR）小鼠与同样处理的LDLR小鼠相比，动脉粥样硬化形成明显减少，但在给予FSH后未减少。接受促性腺激素释放激素拮抗剂与激动剂的LDLR小鼠中较小的斑块负荷在FSHβ：LDLR小鼠中消失。动脉粥样硬化和坏死斑块大小以及巨噬细胞浸润与血清FSH/T相关。在前列腺癌患者中，雄激素剥夺治疗开始后的FSH/T可预测心血管事件。当T水平低或缺乏时，FSH会促进心血管疾病。
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