在睾酮水平低或去势的情况下，促卵泡激素会加重心血管疾病。

Follicle-Stimulating Hormone Exacerbates Cardiovascular Disease in the Presence of Low or Castrate Testosterone Levels.

作者信息

Duivenvoorden Wilhelmina C M, Margel David, Subramony Gayathri Vishal, Duceppe Emmanuelle, Yousef Sadiya, Naeim Magda, Khajehei Mohammad, Hopmans Sarah, Popovic Snezana, Ber Yaara, Heels-Ansdell Diane, Devereaux Philip J, Pinthus Jehonathan H

机构信息

Department of Surgery, Division of Urology, Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada.

Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.

出版信息

JACC Basic Transl Sci. 2023 Dec 20;9(3):364-379. doi: 10.1016/j.jacbts.2023.10.010. eCollection 2024 Mar.

DOI:10.1016/j.jacbts.2023.10.010

PMID:38559622

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10978407/

Abstract

Low testosterone (T), common in aging men, associates with cardiovascular disease. We investigated whether follicle-stimulating hormone (FSH), which is affected by T, modulates the cardiovascular effects associated with low T or castration. FSHβ:low-density lipoprotein receptor (LDLR) mice, untreated or castrated (orchiectomy, gonadotropin-releasing hormone agonist or antagonist), demonstrated significantly less atherogenesis compared with similarly treated LDLR mice, but not following FSH delivery. Smaller plaque burden in LDLR mice receiving gonadotropin-releasing hormone antagonists vs agonists were nullified in FSHβ:LDLR mice. Atherosclerotic and necrotic plaque size and macrophage infiltration correlated with serum FSH/T. In patients with prostate cancer, FSH/T following androgen-deprivation therapy initiation predicted cardiovascular events. FSH facilitates cardiovascular disease when T is low or eliminated.

摘要

低睾酮（T）在老年男性中很常见，与心血管疾病有关。我们研究了受T影响的促卵泡激素（FSH）是否调节与低T或去势相关的心血管效应。未处理或去势（睾丸切除术、促性腺激素释放激素激动剂或拮抗剂）的FSHβ：低密度脂蛋白受体（LDLR）小鼠与同样处理的LDLR小鼠相比，动脉粥样硬化形成明显减少，但在给予FSH后未减少。接受促性腺激素释放激素拮抗剂与激动剂的LDLR小鼠中较小的斑块负荷在FSHβ：LDLR小鼠中消失。动脉粥样硬化和坏死斑块大小以及巨噬细胞浸润与血清FSH/T相关。在前列腺癌患者中，雄激素剥夺治疗开始后的FSH/T可预测心血管事件。当T水平低或缺乏时，FSH会促进心血管疾病。