从海洋盐田沉积物来源合成、分离、优化和表征细胞外L-天冬酰胺酶

Extracellular L-Asparaginase Synthesis Isolation, Optimization, and Characterization from Marine Saltern Sediment Sources.

作者信息

Wahab Mugip Rahaman Abdul, Palaniyandi Thirunavukkarasu, Wyson John, Sivaji Asha, Thamada Swarnakala

机构信息

Department of Biotechnology, Dr. M.G.R Educational and Research Institute, Chennai, Tamil Nadu, India.

Department of Anatomy, Biomedical Research Unit and Laboratory Animal Centre, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India.

出版信息

Avicenna J Med Biotechnol. 2024 Jan-Mar;16(1):40-48. doi: 10.18502/ajmb.v16i1.14170.

DOI:10.18502/ajmb.v16i1.14170

PMID:38605737

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11005392/

Abstract

BACKGROUND

Asparagine is an amino acid that can be converted into aspartic acid and ammonia by the enzyme L-asparaginase. Some forms of cancer, such Acute Lymphoblastic Leukaemia (ALL) and Non-Hodgkin Lymphoma (NHL), respond well to this enzyme when employed as a chemotherapeutic drug. The purpose of this research was to find bacteria that can manufacture the enzymes L-asparaginasein marine slattern sediment which can be employed in commercial and industrial scale production.

METHODS

All of the strains were identified as . by biochemical and molecular testing. The strain belongs to the genus, according to nutritional, biochemical, PCR and 16srRNA sequencing data.

RESULTS

According to the findings of this research, have the potential to create a substance that is helpful in a variety of medical applications. The results of this study hint to the possibility that bacteria have the ability to produce antimicrobial compounds, which have the potential to be successful in a wide variety of environments.

CONCLUSION

Numerous opportunities may arise for researchers interested in utilizing the medical potential of enzyme-producing bacteria if they are successfully isolated and screened from aquatic and terrestrial habitats.

摘要