有细胞质内精子注射史父亲的血管健康。
Vascular health of fathers with history of intracytoplasmic sperm injection.
机构信息
Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Munich, Germany.
Department of Gynecology and Obstetrics, Division of Gynecological Endocrinology and Reproductive Medicine, University Hospital, LMU Munich, Munich, Germany.
出版信息
Aging Male. 2024 Dec;27(1):2360529. doi: 10.1080/13685538.2024.2360529. Epub 2024 Jun 3.
OBJECTIVE
Studies suggest that men who undergo assisted reproductive technologies (ART) may have a higher risk of cardiovascular disease; however, limited data on this matter is available. This observational pilot study aimed to investigate the overall vascular health of fathers with history of intracytoplasmic sperm injection (ICSI) compared to fathers whose partners conceived spontaneously.
METHODS
Diet quality, physical activity, sedentary behavior as well as overall vascular function including the assessment of pulse wave analysis, intima-media thickness (cIMT), arterial stiffness of the common carotid artery (CCA) and blood lipids, were evaluated.
RESULTS
A total of 34 fathers with history of ICSI and 29 controls (48.49 [46.32 - 57.09] years 47.19 [40.62 - 55.18] years, = 0.061) were included. After adjusting for age, no significantly increased cardiovascular risk was detected regarding vascular function.
CONCLUSIONS
The results suggest an unaltered cardiovascular risk profile in fathers with history of ICSI. In the future, prospective multicenter studies are required to validate these preliminary results.
目的
研究表明，接受辅助生殖技术（ART）的男性患心血管疾病的风险可能更高；然而，关于这方面的有限数据。本观察性初步研究旨在调查有卵胞浆内单精子注射（ICSI）史的父亲与自然受孕的父亲相比的整体血管健康状况。
方法
评估了饮食质量、体力活动、久坐行为以及整体血管功能，包括脉搏波分析、内中膜厚度（cIMT）、颈总动脉（CCA）动脉僵硬度和血脂的评估。
结果
共纳入 34 名有 ICSI 史的父亲和 29 名对照组（48.49 [46.32-57.09] 岁和 47.19 [40.62-55.18] 岁，=0.061）。在调整年龄后，血管功能方面未发现明显增加的心血管风险。
结论
结果表明，ICSI 史父亲的心血管风险特征没有改变。未来需要进行前瞻性多中心研究来验证这些初步结果。
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