Chu Lingjun, Wu Yidan, Yin Jiajun, Zhang Kai, Zhong Yiwen, Fan Xiwang, Wang Guoqiang
Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China.
Brain Science Basic Laboratory, The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu, China.
Front Psychiatry. 2024 May 22;15:1350978. doi: 10.3389/fpsyt.2024.1350978. eCollection 2024.
This study aims to examine the potential influence of RS4680 (), RS16965628 (), and RS1019385 () polymorphisms on the therapeutic response to repetitive transcranial magnetic stimulation (rTMS) and selective serotonin reuptake inhibitors (SSRIs) in individuals with obsessive-compulsive disorder (OCD).
Thirty-six untreated outpatients diagnosed with OCD were recruited and allocated to active or sham rTMS groups for two weeks. The mean age of the participants was 31.61, with 17 males (47.22%) and 19 females (52.78%). Peripheral blood samples (5 mL) were collected from each participant using ethylenediaminetetraacetic acid (EDTA) vacuum tubes for genotyping purposes, clinical evaluation was taken place at baseline and second week.
The A allele of RS4680, C allele of RS16965628, and GG allele of RS1019385 were identified as potential bio-markers for predicting treatment response to OCD treatments (rTMS & SSRIs).
Those genes may serve as bio-markers for the combined treatment of rTMS and SSRIs in OCD. The finding hold promise for further research and the potential implementation of precision treatment of OCD.
https://www.chictr.org.cn, identifier ChiCTR1900023641.
本研究旨在探讨RS4680（）、RS16965628（）和RS1019385（）基因多态性对强迫症（OCD）患者重复经颅磁刺激（rTMS）和选择性5-羟色胺再摄取抑制剂（SSRIs）治疗反应的潜在影响。
招募36例未经治疗的门诊强迫症患者，分为rTMS主动治疗组或假刺激组，治疗两周。参与者的平均年龄为31.61岁，其中男性17例（47.22%），女性19例（52.78%）。使用乙二胺四乙酸（EDTA）真空管从每位参与者采集5mL外周血样本用于基因分型，在基线和第二周进行临床评估。
RS4680的A等位基因、RS16965628的C等位基因和RS1019385的GG等位基因被确定为预测强迫症治疗（rTMS和SSRIs）反应的潜在生物标志物。
这些基因可能作为强迫症中rTMS和SSRIs联合治疗的生物标志物。这一发现为进一步研究和强迫症精准治疗的潜在实施带来了希望。
