Elfeky Mariem A, Faraj Saad Rema H, Alabiad Mohamed Ali, Alorini Mohammed, Hemeda Rehab, Ali Ramadan M, Gertallah Loay M, Negm Mohamed, Abdou Ahmed Mahmoud, Alshaikh Ahmed Baker A, Elmaasrawy Ahmed
Department of Pathology, Zagazig University Faculty of Medicine, Zagazig, Egypt.
Department of Pathology, Faculty of Medicine, University of Benghazi, Benghazi, Libya.
Iran J Pathol. 2024 Winter;19(1):10-21. doi: 10.30699/IJP.2023.1971325.2944. Epub 2023 Dec 29.
BACKGROUND & OBJECTIVE: Cervical cancer spreads to the pelvic lymph nodes, leading to a high incidence of cancer recurrence and unfavorable survival rates. Therefore, there is an urgent need to detect new predictive biomarkers for the early assessment of pelvic lymph node status in patients with cervical cancer. The current study aimed to assess the expression of FABP4, GINS2, and CBX7 in cervical cancer tissue to detect their prognostic and predictive roles in developing lymph node metastases in patients with that cancer type. METHODS: We collected the tissues from patients with cervical cancer and evaluated the expression of FABP4, GINS2, and CBX7 using immunohistochemistry. We evaluated the association between their expression and clinicopathological and prognostic parameters. RESULTS: A high expression of FABP4 and GINS2 and a low expression of CBX7 were found to be positively associated with the old age group, large tumor size, high grade and lymphovascular involvement, para-uterine organ infiltration, advanced FIGO stage, chemotherapeutic resistance, and tumor recurrence. CONCLUSION: We demonstrated the oncogenic roles of FABP4 and GISN2 in addition to the on-co-suppressive roles of CBX7 in cervical cancer and their association with poor clinicopathological criteria and poor survival. Our results may indicate that FABP4, GISN2, and CBX7 could be considered predictive biomarkers of the occurrence of lymph node metastases in the cancer of the cervix preoperatively, which could be beneficial in the accurate preoperative design therapy.
背景与目的：宫颈癌可扩散至盆腔淋巴结，导致癌症复发率高及生存率不佳。因此，迫切需要检测新的预测生物标志物，用于早期评估宫颈癌患者的盆腔淋巴结状态。本研究旨在评估脂肪酸结合蛋白4（FABP4）、DNA复制许可因子复合物亚基2（GINS2）和染色体盒蛋白7（CBX7）在宫颈癌组织中的表达，以检测它们在该癌症类型发生淋巴结转移中的预后和预测作用。 方法：我们收集了宫颈癌患者的组织，并采用免疫组织化学方法评估FABP4、GINS2和CBX7的表达。我们评估了它们的表达与临床病理及预后参数之间的关联。 结果：发现FABP4和GINS2的高表达以及CBX7的低表达与老年组、肿瘤体积大、高级别及淋巴管浸润、子宫旁器官浸润、国际妇产科联盟（FIGO）分期晚期、化疗耐药和肿瘤复发呈正相关。 结论：我们证明了FABP4和GINS2在宫颈癌中的致癌作用以及CBX7的肿瘤抑制作用，以及它们与不良临床病理标准和不良生存率的关联。我们的结果可能表明，FABP4、GINS2和CBX7可被视为术前宫颈癌发生淋巴结转移的预测生物标志物，这可能有助于准确的术前治疗设计。
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