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用于生物医学应用的可注射仿生凝胶

Injectable Biomimetic Gels for Biomedical Applications.

作者信息

Omidian Hossein, Wilson Renae L, Dey Chowdhury Sumana

机构信息

Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.

出版信息

Biomimetics (Basel). 2024 Jul 8;9(7):418. doi: 10.3390/biomimetics9070418.

DOI:10.3390/biomimetics9070418
PMID:39056859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274625/
Abstract

Biomimetic gels are synthetic materials designed to mimic the properties and functions of natural biological systems, such as tissues and cellular environments. This manuscript explores the advancements and future directions of injectable biomimetic gels in biomedical applications and highlights the significant potential of hydrogels in wound healing, tissue regeneration, and controlled drug delivery due to their enhanced biocompatibility, multifunctionality, and mechanical properties. Despite these advancements, challenges such as mechanical resilience, controlled degradation rates, and scalable manufacturing remain. This manuscript discusses ongoing research to optimize these properties, develop cost-effective production techniques, and integrate emerging technologies like 3D bioprinting and nanotechnology. Addressing these challenges through collaborative efforts is essential for unlocking the full potential of injectable biomimetic gels in tissue engineering and regenerative medicine.

摘要

仿生凝胶是旨在模仿天然生物系统（如组织和细胞环境）的特性和功能的合成材料。本手稿探讨了可注射仿生凝胶在生物医学应用中的进展和未来方向，并强调了水凝胶因其增强的生物相容性、多功能性和机械性能而在伤口愈合、组织再生和可控药物递送方面的巨大潜力。尽管取得了这些进展，但诸如机械弹性、可控降解速率和可扩展制造等挑战仍然存在。本手稿讨论了正在进行的研究，以优化这些特性、开发具有成本效益的生产技术，并整合3D生物打印和纳米技术等新兴技术。通过合作努力应对这些挑战对于释放可注射仿生凝胶在组织工程和再生医学中的全部潜力至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/39a1d9de4ec3/biomimetics-09-00418-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/5906c72b53d8/biomimetics-09-00418-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/49c228a7a043/biomimetics-09-00418-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/7cbdba6143ee/biomimetics-09-00418-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/0663edae1fd1/biomimetics-09-00418-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/708188596577/biomimetics-09-00418-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/0e2f4c45a3ac/biomimetics-09-00418-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/9cd892caa776/biomimetics-09-00418-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/39a1d9de4ec3/biomimetics-09-00418-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/5906c72b53d8/biomimetics-09-00418-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/49c228a7a043/biomimetics-09-00418-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/7cbdba6143ee/biomimetics-09-00418-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/0663edae1fd1/biomimetics-09-00418-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/708188596577/biomimetics-09-00418-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/0e2f4c45a3ac/biomimetics-09-00418-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/9cd892caa776/biomimetics-09-00418-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4a6/11274625/39a1d9de4ec3/biomimetics-09-00418-g007.jpg

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Cells. 2025 Jan 20;14(2):145. doi: 10.3390/cells14020145.
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