Li Yijie, Li Jie, Li Sen, Zhou Shumin, Yang Jiahua, Xu Ke, Chen Yafeng
Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wenzhou Institute of Shanghai University, Wenzhou, China.
Front Pharmacol. 2024 Jul 26;15:1437894. doi: 10.3389/fphar.2024.1437894. eCollection 2024.
During acute pancreatitis, intestinal permeability increases due to intestinal motility dysfunction, microcirculatory disorders, and ischemia-reperfusion injury, and disturbances in the intestinal flora make bacterial translocation easier, which consequently leads to local or systemic complications such as pancreatic and peripancreatic necrotic infections, acute lung injury, systemic inflammatory response syndrome, and multiple organ dysfunction syndrome. Therefore, adjusting intestinal ecosystem balance may be a promising approach to control local and systemic complications of acute pancreatitis. In this paper, we reviewed the causes and manifestations of intestinal flora disorders during acute pancreatitis and their complications, focused on the reduction of acute pancreatitis and its complications by adjusting the intestinal microbial balance, and innovatively proposed the treatment of acute pancreatitis and its complications by gut microbiota-derived extracellular vesicles.
在急性胰腺炎期间，由于肠道动力功能障碍、微循环障碍和缺血-再灌注损伤，肠道通透性增加，肠道菌群紊乱使细菌易位更容易，从而导致局部或全身并发症，如胰腺和胰周坏死感染、急性肺损伤、全身炎症反应综合征和多器官功能障碍综合征。因此，调节肠道生态系统平衡可能是控制急性胰腺炎局部和全身并发症的一种有前景的方法。在本文中，我们综述了急性胰腺炎期间肠道菌群紊乱的原因和表现及其并发症，重点探讨了通过调节肠道微生物平衡减轻急性胰腺炎及其并发症，并创新性地提出了利用肠道微生物衍生的细胞外囊泡治疗急性胰腺炎及其并发症。
