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母亲接种呼吸道合胞病毒疫苗和 8 月龄以下婴儿接种呼吸道合胞病毒抗体(Nirsevimab)-美国,2024 年 4 月。

Maternal Respiratory Syncytial Virus Vaccination and Receipt of Respiratory Syncytial Virus Antibody (Nirsevimab) by Infants Aged <8 Months - United States, April 2024.

出版信息

MMWR Morb Mortal Wkly Rep. 2024 Sep 26;73(38):837-843. doi: 10.15585/mmwr.mm7338a2.

Abstract

Respiratory syncytial virus (RSV) is the most common cause of hospitalization among U.S. infants. CDC recommends RSV vaccination for pregnant persons or administration of RSV antibody (nirsevimab) to infants aged <8 months to prevent RSV lower respiratory tract disease among infants. To determine maternal and infant RSV immunization coverage for the 2023-24 RSV season, CDC conducted an Internet panel survey during March 26-April 11, 2024. Among 678 women at 32-36 weeks' gestation during September 2023-January 2024, 32.6% reported receipt of an RSV vaccine any time during pregnancy. Among 866 women with an infant born during August 2023-March 2024, 44.6% reported receipt of nirsevimab by the infant. Overall, 55.8% of infants were protected by maternal RSV vaccine, nirsevimab, or both. Provider recommendation for maternal vaccination or infant nirsevimab was associated with higher immunization coverage, whereas lack of a provider recommendation was the main reason for not getting RSV immunization. The main reason for definitely or probably not getting nirsevimab for infants was concern about the long-term safety for the infant. Activities supporting providers to make RSV prevention recommendations and have informative conversations with patients might increase the proportion of infants protected against severe RSV disease. CDC and the American College of Obstetricians and Gynecologists have resources to assist providers in effectively communicating the importance of immunization.

摘要

呼吸道合胞病毒(RSV)是美国婴儿住院的最常见原因。疾病预防控制中心建议对孕妇进行 RSV 疫苗接种,或对 <8 个月大的婴儿给予 RSV 抗体(nirsevimab),以预防婴儿 RSV 下呼吸道疾病。为确定 2023-24 RSV 季节母婴 RSV 免疫接种率,疾病预防控制中心于 2024 年 3 月 26 日至 4 月 11 日期间进行了一项互联网小组调查。在 2023 年 9 月至 2024 年 1 月期间的 32-36 周妊娠期间,678 名妇女中,32.6%报告在怀孕期间的任何时候都接种过 RSV 疫苗。在 2023 年 8 月至 2024 年 3 月期间出生的 866 名婴儿中,44.6%报告婴儿接受了 nirsevimab。总体而言,55.8%的婴儿通过母亲的 RSV 疫苗、nirsevimab 或两者都受到保护。提供者对母亲接种疫苗或婴儿接种 nirsevimab 的建议与更高的免疫接种率相关,而缺乏提供者的建议是未接受 RSV 免疫接种的主要原因。不接种 nirsevimab 的主要原因是对婴儿长期安全性的担忧。支持提供者提出 RSV 预防建议并与患者进行信息交流的活动可能会增加婴儿免受严重 RSV 疾病的保护比例。疾病预防控制中心和美国妇产科医师学会有资源帮助提供者有效传达免疫接种的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/071c/11563570/b6273071ec6f/mm7338a2-F.jpg

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