Suppr超能文献

通过内外信号揭示铜绿假单胞菌感染中的群体感应网络,以防止新的耐药趋势。

Revealing quorum-sensing networks in Pseudomonas aeruginosa infections through internal and external signals to prevent new resistance trends.

机构信息

Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.

Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.

出版信息

Microbiol Res. 2024 Dec;289:127915. doi: 10.1016/j.micres.2024.127915. Epub 2024 Sep 24.

Abstract

In the context of growing antibiotic resistance in bacteria, the quorum-sensing (QS) system of Pseudomonas aeruginosa (P. aeruginosa) has become a target for new therapeutic strategies. QS is a crucial communication process and an essential pathogenic mechanism. This comprehensive review explores the critical role of QS in the pathogenesis of P. aeruginosa infections, including lung, burn, bloodstream, gastrointestinal, corneal, and urinary tract infections. In addition, this review delves into the complexity of the bacterial QS communication network and highlights the intricate mechanisms underlying these pathological processes. Notably, in addition to the four main QS systems, bacterial QS can interact with various external and internal signaling networks, such as host environments and nutrients in the external microbiome, as well as internal virulence regulation systems within bacteria. These elements can significantly influence the behavior and virulence of microbial communities. Therefore, this review reveals that inhibitors targeting singular QS pathways may inadvertently promote virulence in other pathways, leading to new trends in drug resistance. In response to evolving resistance challenges, this study proposes more cautious treatment strategies, including multitarget interventions and combination therapies, aimed at combating the escalating issue of resistance.

摘要

在细菌对抗生素耐药性不断增长的背景下,铜绿假单胞菌(Pseudomonas aeruginosa)的群体感应(QS)系统已成为新治疗策略的目标。QS 是一种至关重要的交流过程和重要的发病机制。本综述探讨了 QS 在铜绿假单胞菌感染发病机制中的关键作用,包括肺部、烧伤、血流、胃肠道、角膜和尿路感染。此外,本综述深入探讨了细菌 QS 通信网络的复杂性,并强调了这些病理过程背后的复杂机制。值得注意的是,除了四个主要的 QS 系统外,细菌 QS 还可以与各种外部和内部信号网络相互作用,例如宿主环境和外部微生物组中的营养物质,以及细菌内部的毒力调节系统。这些因素会极大地影响微生物群落的行为和毒力。因此,本综述揭示了针对单一 QS 途径的抑制剂可能会无意中促进其他途径的毒力,从而导致耐药性的新趋势。为了应对不断演变的耐药性挑战,本研究提出了更谨慎的治疗策略,包括多靶点干预和联合疗法,旨在对抗日益严重的耐药问题。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验