儿童青少年 Gilles de la Tourette 综合征生活质量量表（GTS-QOL）中文版的心理测量学特性。

The psychometric properties of Chinese version of the Gilles de la Tourette syndrome-quality of life scale (GTS-QOL) for children and adolescents.

机构信息

Department of Psychiatry, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.

出版信息

BMC Psychiatry. 2024 Oct 23;24(1):722. doi: 10.1186/s12888-024-06149-5.

DOI:10.1186/s12888-024-06149-5

PMID:39443913

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11515785/

Abstract

BACKGROUND

Gilles de la Tourette syndrome (GTS) is a persistent neurological disorder that profoundly affects the quality of life for afflicted individuals, however, tailored health-related quality of life (QOL) measures for Chinese pediatric GTS patients are lacking. This pioneering study aims to develop a QOL scale for Chinese children with GTS.

METHODS

A cohort of 1,121 children (aged 6-16 years) diagnosed with GTS participated in scale development. Internal consistency was evaluated using Cronbach's alpha. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed to assess the factor structure of the GTS-QOL-Chinese, examining goodness-of-fit indices, factor loadings of individual items, and covariances between factors. Validity was determined through interscale correlations and comparisons with external measures to establish convergent and discriminant validity.

RESULTS

Following reliability and validity analyses, a Chinese version of the 24-item GTS-specific quality of life scale was conclusively established, encompassing five subscales (psychological, compulsive, cognitive, physical, social). The scale demonstrated high internal consistency with a Cronbach's alpha coefficient of 0.93, and validity was substantiated through interscale correlations ranging from 0.46 to 0.68. EFA identified five factors, explaining 61.26% of the total variation. CFA further confirmed the scale's robustness, with all goodness-of-fit indicators meeting acceptable criteria (AGFI = 0.86, PCFI = 0.78, GFI = 0.89, CFI = 0.89, RMSEA = 0.07, SRMR = 0.06).

CONCLUSIONS

The Chinese version of the GTS-QOL scale has exhibits robust reliability and validity and is valuable for assessing the quality of life of Chinese children and adolescents with GTS. This scale may assist in tailoring interventions and improving patient care.

摘要

背景

妥瑞氏症候群（Gilles de la Tourette syndrome，GTS）是一种持续存在的神经疾病，严重影响患者的生活质量，但缺乏针对中国儿科 GTS 患者的健康相关生活质量（QOL）测量工具。本研究旨在为中国 GTS 患儿开发一种 QOL 量表。

方法

共纳入 1121 名 GTS 患儿（年龄 6-16 岁）参与量表制定。采用 Cronbach's alpha 评估内部一致性。采用探索性因子分析（EFA）和验证性因子分析（CFA）评估 GTS-QOL-Chinese 的因子结构，考察拟合优度指标、各条目因子负荷及因子间协方差。通过量表间相关性和与外部测量值的比较来确定效标关联效度和区分效度。

结果

经过信度和效度分析，最终确立了包含 24 个条目的 GTS 特异性生活质量量表中文版，包含 5 个分量表（心理、强迫、认知、躯体、社会）。量表的 Cronbach's alpha 系数为 0.93，表明具有较高的内部一致性。量表间相关性为 0.46-0.68，进一步证实了其效度。EFA 确定了 5 个因子，解释了总变异的 61.26%。CFA 进一步验证了量表的稳健性，所有拟合优度指标均符合可接受标准（AGFI=0.86，PCFI=0.78，GFI=0.89，CFI=0.89，RMSEA=0.07，SRMR=0.06）。