癌胚抗原相关细胞黏附分子1在癌症中：是福还是祸？

Carcinoembryonic antigen-related cell adhesion molecule 1 in cancer: Blessing or curse?

作者信息

Götz Lisa, Rueckschloss Uwe, Najjar Sonia M, Ergün Süleyman, Kleefeldt Florian

机构信息

Institute of Anatomy and Cell Biology, University of Wuerzburg, Wuerzburg, Germany.

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Irvine Hall, Ohio University, Athens, Ohio, USA.

出版信息

Eur J Clin Invest. 2024 Dec;54 Suppl 2(Suppl 2):e14337. doi: 10.1111/eci.14337. Epub 2024 Oct 25.

DOI:10.1111/eci.14337

PMID:39451132

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11646294/

Abstract

The Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, also CD66a), a transmembrane glycoprotein of the immunoglobulin superfamily, is a pivotal mediator of various physiological and pathological processes, including oncologic disorders. However, its precise role in tumorigenicity is contradictory discussed by several clinical studies. This review aims to elucidate the clinical significance of CEACAM1 in different cancer entities focusing on tumour formation, progression and metastasis as well as on CEACAM1-mediated treatment resistance. Furthermore, we discuss the contribution of CEACAM1 to cancer immunity and modulation of the inflammatory microenvironment and finally provide a comprehensive review of treatment regimens targeting this molecule.

摘要

癌胚抗原相关细胞黏附分子1（CEACAM1，也称为CD66a）是免疫球蛋白超家族的一种跨膜糖蛋白，是包括肿瘤疾病在内的各种生理和病理过程的关键介质。然而，几项临床研究对其在肿瘤发生中的精确作用存在相互矛盾的讨论。本综述旨在阐明CEACAM1在不同癌症实体中的临床意义，重点关注肿瘤形成、进展和转移以及CEACAM1介导的治疗耐药性。此外，我们讨论了CEACAM1对癌症免疫和炎症微环境调节的贡献，最后对靶向该分子的治疗方案进行了全面综述。