Wang Jian, Zhang Yuanwei, Wang Sicheng, Wang Xinglong, Jing Yingying, Su Jiacan
Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Trauma Orthopedics Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; School of Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai 200444, China.
Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Trauma Orthopedics Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Musculoskeletal Injury and Translational Medicine of Organoids, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai 200444, China.
Sci Bull (Beijing). 2024 Dec 30;69(24):3978-3999. doi: 10.1016/j.scib.2024.10.013. Epub 2024 Oct 16.
Bone aging, a major global health concern, is the natural decline in bone mass and strength. Concurrently, extracellular vesicles (EVs), tiny membrane-bound particles produced by cells, have gained recognition for their roles in various physiological processes and age-related diseases. The interaction between EVs and bone aging is of growing interest, particularly their effects on bone metabolism, which become increasingly critical with advancing age. In this review, we explored the biology, types, and functions of EVs and emphasized their regulatory roles in bone aging. We examined the effects of EVs on bone metabolism and highlighted their potential as biomarkers for monitoring bone aging progression. Furthermore, we discussed the therapeutic applications of EVs, including targeted drug delivery and bone regeneration, and addressed the challenges associated with EV-based therapies, including the technical complexities and regulatory issues. We summarized the current research and clinical trials investigating the role of EVs in bone aging and suggested future research directions. These include the potential for personalized medicine using EVs and the integration of EV research with advanced technologies to enhance the management of age-related bone health. This analysis emphasized the transformative potential of EVs in understanding and managing bone aging, thereby marking a significant advancement in skeletal health research.
骨老化是一个全球主要的健康问题，指的是骨量和骨强度的自然下降。与此同时，细胞外囊泡（EVs），即细胞产生的微小膜结合颗粒，因其在各种生理过程和与年龄相关疾病中的作用而受到关注。EVs与骨老化之间的相互作用越来越受到关注，尤其是它们对骨代谢的影响，随着年龄的增长，这种影响变得越来越重要。在这篇综述中，我们探讨了EVs的生物学特性、类型和功能，并强调了它们在骨老化中的调节作用。我们研究了EVs对骨代谢的影响，并突出了它们作为监测骨老化进展生物标志物的潜力。此外，我们讨论了EVs的治疗应用，包括靶向药物递送和骨再生，并阐述了基于EVs疗法相关的挑战，包括技术复杂性和监管问题。我们总结了当前研究和临床试验中关于EVs在骨老化中作用的情况，并提出了未来的研究方向。这些方向包括使用EVs实现个性化医疗的潜力，以及将EVs研究与先进技术相结合以加强对与年龄相关骨健康的管理。这一分析强调了EVs在理解和管理骨老化方面的变革潜力，从而标志着骨骼健康研究取得了重大进展。
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