Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, China.
World J Gastroenterol. 2024 Oct 21;30(39):4318-4323. doi: 10.3748/wjg.v30.i39.4318.
This article reviews of the original research published by Wu in the , delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease (CD). Insights were gained from fecal microbiota transplantation (FMT) in mouse models, revealing the intricate interplay between the gut microbiota, mesenteric adipose tissue (MAT), and creeping fat. The study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD; moreover, through the FMT mouse model, it observed the impact of samples from healthy patients and those with CD on symptoms. The pathogenesis of CD is complex, and its etiology remains unclear; however, it is widely believed that gut microbiota dysbiosis plays a significant role. Recently, with the development and application of next-generation sequencing technology, research on the role of fungi in the pathogenesis and chronicity of CD has deepened. This editorial serves as a supplement to the research by Wu who discussed advances related to the study of fungi in CD.
本文综述了 Wu 近期发表于《柳叶刀-胃肠病学和肝脏病学》的一项原创研究，深入探讨了肠道微生物群在克罗恩病（CD）发病机制中的关键作用。该研究通过粪菌移植（FMT）的小鼠模型揭示了肠道微生物群、肠系膜脂肪组织（MAT）和匍匐脂肪之间的复杂相互作用，发现了 CD 患者 MAT 和肠道组织中的炎症和纤维化特征；此外，通过 FMT 小鼠模型，观察了来自健康患者和 CD 患者样本对症状的影响。CD 的发病机制复杂，其病因尚不清楚；然而，人们普遍认为肠道微生物群失调起重要作用。最近，随着下一代测序技术的发展和应用，对真菌在 CD 发病机制和慢性化中的作用的研究也在不断深入。本社论是对 Wu 研究的补充，Wu 讨论了与 CD 中真菌研究相关的进展。
