Zhang Yingying, Chen Guangxi, Huang Aixia, Hu Ying, Fu Chengfeng
Department of Laboratory Medicine, Affiliated Wuxi Fifth Hospital of Jiangnan University, Wuxi, China.
Respiratory and Critical Care Medicine, the Second People's Hospital of Banan District, Chongqing, China.
Chronic Obstr Pulm Dis. 2025 Jan 29;12(1):61-71. doi: 10.15326/jcopdf.2024.0573.
Chronic obstructive pulmonary disease (COPD) is closely associated with arthritis. This study aims to evaluate the correlation between COPD and mortality among participants with arthritis.
The study included 11,298 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, who self-reported having arthritis. Cox proportional hazard models were used to assess the association between COPD and mortality among participants with arthritis. Kaplan-Meier survival curves were plotted to compare survival probabilities between groups. Subgroup and sensitivity analyses were conducted to assess the robustness of the results.
During an average follow-up of 8.8 years, 3061 all-cause deaths were observed, including 1024 related to cardiovascular disease (CVD). After weighted multivariable adjustment, COPD was found to be significantly associated with both all-cause and CVD mortality among these arthritis participants. The hazard ratio (HR) for all-cause mortality among arthritis patients with COPD was 1.41 (95% confidence interval [CI]: 1.25-1.60, < 0.001), and the HR for CVD mortality was 1.29 (95% CI: 1.08-1.53, < 0.001). Kaplan-Meier survival curves attributed higher rates of both all-cause and CVD mortality among participants with COPD compared to those without (log-rank test, < 0.001). Additionally, COPD increased the risk of both chronic lower respiratory disease (CLRD) mortality (HR 5.46, 95% CI: 3.48-8.56, < 0.001) and non-CLRD mortality (HR 1.24, 95% CI: 1.07-1.44, =0.004).
In the American population, arthritis patients with COPD have higher risks of all-cause and CVD mortality compared to those without COPD.
慢性阻塞性肺疾病（COPD）与关节炎密切相关。本研究旨在评估COPD与关节炎患者死亡率之间的相关性。
该研究纳入了1999 - 2018年美国国家健康与营养检查调查（NHANES）中的11298名自我报告患有关节炎的参与者。采用Cox比例风险模型评估COPD与关节炎患者死亡率之间的关联。绘制Kaplan - Meier生存曲线以比较各组之间的生存概率。进行亚组分析和敏感性分析以评估结果的稳健性。
在平均8.8年的随访期间，观察到3061例全因死亡，其中1024例与心血管疾病（CVD）相关。经过加权多变量调整后，发现COPD与这些关节炎参与者的全因死亡率和CVD死亡率均显著相关。患COPD的关节炎患者全因死亡率的风险比（HR）为1.41（95%置信区间[CI]：1.25 - 1.60，P < 0.001），CVD死亡率的HR为1.29（95%CI：1.08 - 1.53，P < 0.001）。Kaplan - Meier生存曲线显示，与未患COPD的参与者相比，患COPD的参与者全因死亡率和CVD死亡率均更高（对数秩检验，P < 0.001）。此外，COPD增加了慢性下呼吸道疾病（CLRD）死亡率（HR 5.46，95%CI：3.48 - 8.56，P < 0.001）和非CLRD死亡率（HR 1.24，95%CI：1.07 - 1.44，P = 0.004）的风险。
在美国人群中，与未患COPD的关节炎患者相比，患COPD的关节炎患者全因死亡率和CVD死亡率风险更高。
