Fungal nomenclature has been subject to change for many years and will probably continue to evolve and change in the future. One Fungus One Name principle guided the mycologists to reach a consensus on a single name. The change is inevitable in science; however, it comes with several challenges particularly in routine mycology laboratory practice and patient care, creating further difficulties and resistance to change. To overcome these challenges, the reason for change should be clear and made available on a publicly accessible source. Here, the changes of names in medically important fungi and the rationale behind are summarized.