Wang Xiaomeng, Hong Yue, Zou Jinmei, Zhu Bo, Jiang Chao, Lu Liwei, Tian Jie, Yang Jing, Rui Ke
Department of Laboratory Medicine, Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Biomark Res. 2025 Jan 29;13(1):22. doi: 10.1186/s40364-025-00733-x.
As a member of the Activator Protein-1 (AP-1) transcription factor family, the Basic Leucine Zipper Transcription Factor (BATF) mediates multiple biological functions of immune cells through its involvement in protein interactions and binding to DNA. Recent studies have demonstrated that BATF not only plays pivotal roles in innate and adaptive immune responses but also acts as a crucial factor in the differentiation and function of various immune cells. Lines of evidence indicate that BATF is associated with the onset and progression of allergic diseases, graft-versus-host disease, tumors, and autoimmune diseases. This review summarizes the roles of BATF in the development and function of innate and adaptive immune cells, as well as its immunoregulatory effects in the development of autoimmune diseases, which may enhance the current understanding of the pathogenesis of autoimmune diseases and facilitate the development of new therapeutic strategies.
作为激活蛋白-1（AP-1）转录因子家族的一员，碱性亮氨酸拉链转录因子（BATF）通过参与蛋白质相互作用和与DNA结合来介导免疫细胞的多种生物学功能。最近的研究表明，BATF不仅在先天性和适应性免疫反应中起关键作用，而且在各种免疫细胞的分化和功能中也起着至关重要的因素。有证据表明，BATF与过敏性疾病、移植物抗宿主病、肿瘤和自身免疫性疾病的发生和发展有关。这篇综述总结了BATF在先天性和适应性免疫细胞的发育和功能中的作用，以及其在自身免疫性疾病发展中的免疫调节作用，这可能会加深目前对自身免疫性疾病发病机制的理解，并促进新治疗策略的开发。
