在长轴视野PET/CT扫描仪上使用[F]SiTATE进行低活性[F] - 生长抑素受体（SSTR）成像。
Low-activity [F]-somatostatin receptor (SSTR) imaging using [F]SiTATE on a long axial field-of-view PET/CT scanner.
作者信息
Trautwein Nils F, Calderón Eduardo, Linder Pia M, Reischl Gerald, Driessen Philippe, Lan Wenhong, Brendlin Andreas S, Groß Thorben, Dittmann Helmut, Hinterleitner Martina, Fougère Christian la, Schmidt Fabian P, Kiefer Lena S
机构信息
Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Otfried-Mueller-Str. 14, 72076, Tuebingen, Germany.
ENETS Center of Excellence, University Hospital Tuebingen, Otfried-Mueller-Str. 14, 72076, Tuebingen, Germany.
出版信息
EJNMMI Phys. 2025 Feb 5;12(1):13. doi: 10.1186/s40658-025-00720-z.
PURPOSE
F-labelled somatostatin receptor tracers have recently gained popularity due to their better spatial resolution, longer half-life and lower costs compared to Ga-labeled tracers. The aim of this study was to evaluate the impact and limitations of reduced administered activities of [F]SiTATE on image quality, lesion detectability and quantitative PET parameters in a long axial field-of-view (LAFOV) PET/CT scanner.
METHODS
Twenty-four patients with histologically confirmed neuroendocrine tumor, who underwent clinically indicated [F]SiTATE PET/CT examination (3.0 MBq/kg, 5 min PET scan time) on a Siemens Biograph Vision Quadra LAFOV PET/CT, were included retrospectively in this study. PET list-mode data were rebinned for shorter frame durations to simulate 5 min scans with lower activities of injected radiotracer. A comparison of image reconstruction in high sensitivity (HS) and ultra-high sensitivity mode (UHS) mode was performed. Subjective image quality, noise and lesion detectability of n = 122 lesions were rated using a 5-point Likert scale. The molecular tumor volume (MTV), signal-to-noise ratio (SNR), tumor-to-liver activity concentration ratio (TLR) and standardized uptake values (SUV) were analyzed.
RESULTS
Subjective image quality decreased with simulated reduction of injected activity with generally superior ratings in the UHS mode compared to the HS mode. Despite a reduction to 1 MBq/kg of [F]SiTATE all lesions were still detected while at 0.25 MBq/kg lesion detectability decreased to 70% (HS) and 93% (UHS). Only minor changes in SUV and TLR were detected with reduced activity. However, reduced activities led to an increase in SUV, which in turn caused a decrease in SNR (at 1 MBq/kg: 7.3 in HS and 9.0 in UHS mode and an increase in deviation of the MTV.
CONCLUSION
Reducing the administered activity of injected [F]SiTATE by 66% to 1 MBq/kg (HS & UHS) is feasible in a LAFOV PET/CT scanner, maintaining clinically diagnostic image quality without statistically significant deviations in PET uptake parameters and MTV. Furthermore, in low activity [F]SiTATE PET/CT, the UHS mode improves image quality and noise as well as lesion detectability compared to HS mode, further reinforcing the clinical benefits of this recently introduced reconstruction mode.
目的
与镓标记的示踪剂相比，氟标记的生长抑素受体示踪剂因其具有更好的空间分辨率、更长的半衰期和更低的成本，近来受到广泛关注。本研究的目的是评估在长轴视野（LAFOV）PET/CT扫描仪中，降低[F]SiTATE给药活度对图像质量、病灶可探测性和PET定量参数的影响及局限性。
方法
本研究回顾性纳入了24例经组织学确诊的神经内分泌肿瘤患者，这些患者在西门子Biograph Vision Quadra LAFOV PET/CT上接受了临床指征的[F]SiTATE PET/CT检查（3.0 MBq/kg，PET扫描时间5分钟）。对PET列表模式数据重新进行分箱，以缩短帧持续时间，从而模拟注射放射性示踪剂活度较低时的5分钟扫描。进行了高灵敏度（HS）和超高灵敏度模式（UHS）下的图像重建比较。使用5点李克特量表对n = 122个病灶的主观图像质量、噪声和病灶可探测性进行评分。分析了分子肿瘤体积（MTV）、信噪比（SNR）、肿瘤与肝脏活度浓度比（TLR）和标准化摄取值（SUV）。
结果
随着模拟注射活度的降低，主观图像质量下降，与HS模式相比，UHS模式下的评分总体更高。尽管[F]SiTATE活度降至1 MBq/kg，但所有病灶仍可被检测到，而当活度降至0.25 MBq/kg时，病灶可探测性在HS模式下降至70%，在UHS模式下降至93%。活度降低时，仅SUV和TLR有轻微变化。然而，活度降低导致SUV升高，进而导致SNR降低（在1 MBq/kg时：HS模式下为7.3，UHS模式下为9.0），MTV偏差增加。
结论
在LAFOV PET/CT扫描仪中，将注射的[F]SiTATE给药活度降低66%至1 MBq/kg（HS和UHS）是可行的，可保持临床诊断图像质量，PET摄取参数和MTV无统计学显著偏差。此外，在低活度[F]SiTATE PET/CT中，与HS模式相比，UHS模式可改善图像质量、噪声以及病灶可探测性，进一步强化了这种新引入的重建模式的临床优势。
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