Wang Mo, Song Sixian, Li Dan, Zhao Guangchao, Luo Yu, Tian Yi, Zhang Jiajia, Liu Quanying, Wei Pengfei
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Neurosci Bull. 2025 Apr 11. doi: 10.1007/s12264-025-01387-3.
Transcranial temporal interference stimulation (tTIS) is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures. This study explores the neural and behavioral effects of tTIS on the superior colliculus (SC), a region involved in eye movement control, in mice. Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation. In vivo experiments, including Ca signal recordings and eye movement tracking, showed that tTIS effectively modulates SC neural activity and induces eye movements. A significant correlation was found between stimulation frequency and saccade frequency, suggesting direct tTIS-induced modulation of SC activity. These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements, highlighting its potential for neuroscientific research and therapeutic applications.
经颅颞叶干扰刺激（tTIS）是一种新型的非侵入性神经调节技术，具有精确靶向深部脑结构的潜力。本研究探讨了tTIS对小鼠上丘（SC）的神经和行为影响，上丘是一个参与眼球运动控制的区域。计算模型显示，与传统经颅交流电刺激相比，tTIS对上丘的刺激更集中。体内实验，包括钙信号记录和眼球运动跟踪，表明tTIS能有效调节上丘神经活动并诱发眼球运动。刺激频率与扫视频率之间存在显著相关性，表明tTIS直接诱导了对上丘活动的调节。这些结果证明了tTIS在靶向深部脑区和调节眼球运动方面的精确性，突出了其在神经科学研究和治疗应用中的潜力。
