端粒长度在体力活动与表型年龄关系中的中介作用：一项基于人群的研究。

Mediation role of telomere length in the relationship between physical activity and PhenoAge: A population-based study.

作者信息

You Yanwei, Wang Dizhi, Ding Hao, Wang Weizhao, Liu Qiyu, Zhang Danyi, Chen Yuquan, Ma Xindong

机构信息

Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China.

IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, 100084, China.

出版信息

J Exerc Sci Fit. 2025 Jul;23(3):149-156. doi: 10.1016/j.jesf.2025.03.004. Epub 2025 Mar 26.

DOI:10.1016/j.jesf.2025.03.004

PMID:40235556

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11994304/

Abstract

BACKGROUND

The relationship between physical activity (PA), telomere length, and phenotypic age (PhenoAge) represents a pivotal area of investigation in aging research.

METHODS

The study encompassed a cohort of 6200 participants aged 20 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES). Physical activity (PA) levels were assessed employing the Global Physical Activity Questionnaire, while DNA samples were collected to determine telomere length, measured in base pairs. PhenoAge, an emerging aging index relying on nine distinct chemical biomarkers, was computed.

RESULTS

Incorporating a fully adjusted model, our analysis showed significant correlations between PA engagement and PhenoAge [Low PA, β (95 % CI): 0.039(-0.071,-0.008), p = 0.021; Moderate PA, β (95 % CI): 0.058(-0.082,-0.034), p < 0.001; High PA, β (95 % CI): 0.069(-0.096,-0.042), p < 0.001]. Furthermore, a positive link emerged between elevated PA levels and telomere length, with a β (95 % CI) of 0.011(0.001, 0.022), p = 0.034. A mediation analysis was performed, demonstrating that telomere length mediated the connection between PA and PhenoAge, with a proportion mediated calculated at 3.57 %.

CONCLUSIONS

Our findings suggest that PA may play a key role in mitigating aging processes by preserving telomere length, highlighting the potential of PA as a target for interventions aimed at promoting healthy aging and longevity.

摘要

背景

体力活动（PA）、端粒长度与表型年龄（PhenoAge）之间的关系是衰老研究中的一个关键调查领域。

方法

该研究纳入了6200名年龄在20岁及以上的参与者，他们来自国家健康与营养检查调查（NHANES）。使用全球体力活动问卷评估体力活动（PA）水平，同时收集DNA样本以确定端粒长度，以碱基对为单位进行测量。计算了PhenoAge，这是一种依赖于九种不同化学生物标志物的新兴衰老指数。

结果

在纳入完全调整模型后，我们的分析表明PA参与度与PhenoAge之间存在显著相关性[低PA，β（95%CI）：0.039（-0.071，-0.008），p = 0.021；中度PA，β（95%CI）：0.058（-0.082，-0.034），p < 0.001；高PA，β（95%CI）：0.069（-0.096，-0.042），p < 0.001]。此外，PA水平升高与端粒长度之间出现了正相关，β（95%CI）为0.011（0.001，0.022），p = 0.034。进行了中介分析，结果表明端粒长度介导了PA与PhenoAge之间的联系，计算得出的中介比例为3.57%。