Coral reef degradation has captured global attention from governments, conservationists, and researchers, who are making concerted efforts to develop sustainable solutions to support reef resilience in the face of environmental degradation. The goal is to empower local community efforts for effective marine resource management. However, one of the major barriers to coral conservation is the lack of timely and affordable population-level health data, which can delay effective management responses. Although progress has been made in understanding the molecular basis of coral health outcomes, more translational work is needed to develop cost-effective, point-of-care (POC) diagnostic tools for real-time monitoring. This review assesses the current state of translational omics-based research for coral health monitoring, focusing on highlighting key gaps and actionable next steps to guide the implementation of effective, field-ready tools for monitoring coral disease, reproduction, and thermal stress. These advancements can be used to advance urgent conservation needs and promote reef management by local communities.