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左旋布比卡因局部应用对小儿扁桃体切除术后结局影响的前瞻性观察队列研究

Prospective Observational Cohort Study of the Effect of Topical Levobupivacaine on Post-Operative Outcomes for Paediatric Patients Undergoing Tonsillectomy.

作者信息

Mettias Bassem, Twigg Victoria, Kamani Tawakir

机构信息

Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, England.

ENT Department, Basildon Hospital - Mid and South Essex NHS foundation Trust, Basildon, England.

出版信息

Indian J Otolaryngol Head Neck Surg. 2025 May;77(5):2104-2109. doi: 10.1007/s12070-025-05465-w. Epub 2025 Apr 19.

Abstract

The efficacy of topical anaesthetic in children undergoing tonsillectomy is controversial. It can block sensory signals along C-fibres. Observational study of pain after cold-steel tonsillectomy. Two cohorts; one with topical levobupivacaine soaked swab in the tonsil bed and a second without. FACES scale and visual analogue score were used. Other parameters were oral intake, hospital stays and use of oral morphine. 74-enrolled patients whose parents completed feedback telephone reviews. 37-patients had topical levobupivacaine. There was no difference in pain and analgesic needs between both cohorts on the first two days. Local anaesthesia induced a significant rebound pain on the fifth day. Early use of oral morphine and female gender showed a significant correlation with rebound pain. Topical levobupivacaine showed limited control of early postoperative tonsillectomy pain with rebound pain on the fifth day. Female gender and early opioid use postoperatively increased the risk of rebound pain.

摘要

局部麻醉药在接受扁桃体切除术的儿童中的疗效存在争议。它可以阻断沿C纤维的感觉信号。对冷钢扁桃体切除术后疼痛的观察性研究。两个队列;一个在扁桃体床使用左旋布比卡因浸湿的拭子,另一个不使用。使用面部表情量表和视觉模拟评分。其他参数包括口服摄入量、住院时间和口服吗啡的使用情况。74名登记患者的父母完成了反馈电话回访。37名患者使用了局部左旋布比卡因。在前两天,两个队列在疼痛和镇痛需求方面没有差异。局部麻醉在第五天引起了明显的反跳痛。早期使用口服吗啡和女性性别与反跳痛有显著相关性。局部左旋布比卡因对扁桃体切除术后早期疼痛的控制有限,且在第五天出现反跳痛。女性性别和术后早期使用阿片类药物增加了反跳痛的风险。

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