Ulriksdotter Josefin, Sukakul Thanisorn, Bruze Magnus, Hamnerius Nils, Mowitz Martin, Svedman Cecilia
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
J Diabetes Sci Technol. 2025 May 7:19322968251336261. doi: 10.1177/19322968251336261.
Adverse skin reactions to continuous glucose monitors (CGMs) and devices for continuous subcutaneous insulin infusions (CSIIs) ("diabetes medical devices" (MDs)) are well known. However, epidemiological studies on prevalence and skin rash details are lacking. The objective of this study was to describe the prevalence and details of skin rash to diabetes MDs in adults with type 1 diabetes.
All adult individuals (≥18 years) with type 1 diabetes attending outpatient diabetes clinics at two hospitals in southern Sweden were invited to participate (n = 1943) in a questionnaire study.
The questionnaire was completed by 667. Of the respondents 95.1% had used CGM and 36.7% had used CSII. Skin rash to the devices was reported by 42.1% of CGM users and 44.9% of CSII users. Skin rash was reported with use of all types of diabetes MDs. For diabetes MDs with ≥50 users, 18.0% to 56.5% of the participants with skin rash had to change the device more often than recommended and 4.0% to 18.0% had to stop using the device due to skin rash. In multivariable analyses, the odds for skin rash to diabetes MDs were higher among younger individuals and individuals with childhood atopic dermatitis. Odds increased with use of higher numbers of devices. Of the participants with skin rash, 13 of the 289 (4.5%) had been investigated for contact allergy.
Skin rash to diabetes MDs is common. The problem is underdiagnosed in clinical practice. With use of diabetes MDs expected to increase, an increasing prevalence of skin rash is to be expected.
连续血糖监测仪（CGM）和持续皮下胰岛素输注装置（CSII）（“糖尿病医疗设备”（MDs））引起的皮肤不良反应是众所周知的。然而，关于其患病率和皮疹细节的流行病学研究却很缺乏。本研究的目的是描述1型糖尿病成年患者中糖尿病MDs引起皮疹的患病率和细节。
邀请瑞典南部两家医院门诊糖尿病诊所的所有成年1型糖尿病患者（≥18岁）（n = 1943）参与一项问卷调查研究。
667人完成了问卷。在受访者中，95.1%使用过CGM，36.7%使用过CSII。42.1%的CGM使用者和44.9%的CSII使用者报告了设备引起的皮疹。所有类型的糖尿病MDs使用时均有皮疹报告。对于使用者≥50人的糖尿病MDs，18.0%至56.5%有皮疹的参与者不得不比推荐的更频繁地更换设备，4.0%至18.0%的人因皮疹不得不停止使用该设备。在多变量分析中，年轻个体和有儿童期特应性皮炎的个体中糖尿病MDs引起皮疹的几率更高。皮疹几率随着使用设备数量的增加而增加。在有皮疹的参与者中，289人中有13人（4.5%）接受了接触性过敏调查。
糖尿病MDs引起的皮疹很常见。该问题在临床实践中诊断不足。随着糖尿病MDs的使用预计会增加，皮疹患病率预计也会上升。
