Kebede Michael A, Matthews Charles E, Dunn Matthew R, Burse Natasha R, Howard Annie G, Evenson Kelly R, Troester Melissa A
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Cancer Med. 2025 May;14(10):e70884. doi: 10.1002/cam4.70884.
Moderate to vigorous physical activity (MVPA) after breast cancer diagnosis is associated with improved survivorship. However, differences in MVPA by race among breast cancer survivors are not well described in population-based studies.
We analyzed data from Carolina Breast Cancer Study Phase 3 (n = 2994, 50% Black) participants to evaluate the trajectory of MVPA from pre-diagnosis to 18-month post-diagnosis. Participants self-reported MVPA at baseline (pre-diagnosis) and 6- and 18-month post-diagnosis and were classified as having any MVPA (> 0 min/week) or no MVPA. Associations between MVPA and demographic, social, and clinical variables were estimated using multivariable logistic regression.
At baseline, 84.0% of participants reported any MVPA pre-diagnosis, which dropped to 55.4% at 6-month post-diagnosis, then rebounded to 85.1% by 18-month post-diagnosis. Among those who had no MVPA pre-diagnosis, 32.5% and 71.0% became active at 6- and 18-month post-diagnosis, respectively. Higher income [adjusted odds ratio (aOR) = 1.33, 95% confidence interval (CI) (1.02, 1.74) > $30K vs. < 15K], lower body mass index [aOR = 1.30, 95% CI (1.00, 1.73) < 25 vs. > 30], low area deprivation [aOR = 1.35, 95% CI (1.08, 1.67) vs. high], high area assets [aOR = 1.54, 95% CI (1.23, 1.93) vs. low], and stage I breast cancer [aOR = 1.72, 95% CI (1.22, 2.43) vs. 3 or 4] were associated with any MVPA at 18-month post-diagnosis.
We identified several demographic and social correlates of any MVPA at 18-month post-diagnosis, and together with established clinical correlates (such as late disease), these factors may contribute to breast cancer disparities.
乳腺癌确诊后进行中度至剧烈体育活动（MVPA）与提高生存率相关。然而，基于人群的研究中并未充分描述乳腺癌幸存者中MVPA在种族方面的差异。
我们分析了卡罗来纳乳腺癌研究第三阶段（n = 2994，50%为黑人）参与者的数据，以评估从诊断前到诊断后18个月MVPA的变化轨迹。参与者在基线（诊断前）、诊断后6个月和18个月自行报告MVPA情况，并被分类为有任何MVPA（>0分钟/周）或无MVPA。使用多变量逻辑回归估计MVPA与人口统计学、社会和临床变量之间的关联。
在基线时，84.0%的参与者报告在诊断前有任何MVPA，在诊断后6个月降至55.4%，然后在诊断后18个月回升至85.1%。在诊断前无MVPA的参与者中，分别有32.5%和71.0%在诊断后6个月和18个月开始活跃起来。较高收入[调整后的优势比（aOR）= 1.33，95%置信区间（CI）（1.02，1.74），收入>30000美元与<15000美元相比]、较低体重指数[aOR = 1.30，95%CI（1.00，1.73），体重指数<25与>30相比]、低地区贫困程度[aOR = 1.35，95%CI（1.08，1.67），与高贫困程度相比]、高地区资产[aOR = 1.54，95%CI（1.23，1.93），与低资产相比]以及I期乳腺癌[aOR = 1.72，95%CI（1.22，2.43），与III期或IV期相比]与诊断后18个月有任何MVPA相关。
我们确定了诊断后18个月有任何MVPA的几个人口统计学和社会相关因素，并且与已确定的临床相关因素（如疾病晚期）一起，这些因素可能导致乳腺癌差异。
