抗阻训练男性补充L-瓜氨酸与L-瓜氨酸-DL-苹果酸六周后，抗阻训练表现、主观用力感觉评分及血液生物标志物的变化：一项双盲安慰剂对照试验

Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial.

作者信息

Bayat Davoud, Azizi Mohammad, Behpour Naser, Tinsley Grant M

机构信息

Razi University, Department of Exercise Physiology, Faculty of Sport Sciences, Kermanshah, Iran.

Texas Tech University, Department of Kinesiology & Sport Management, Lubbock, TX, USA.

出版信息

J Int Soc Sports Nutr. 2025 Dec;22(1):2513944. doi: 10.1080/15502783.2025.2513944. Epub 2025 Jun 5.

DOI:10.1080/15502783.2025.2513944

PMID:40470618

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12143003/

Abstract

PURPOSE

This study aimed to investigate and compare the effects of chronic supplementation with L-Citrulline (LC) vs. L-Citrulline DL-malate (CM) on resistance training (RT) performance.

METHODS

Thirty-three resistance-trained men were randomly assigned to ingest LC (8 g), CM (12 g), or Placebo (PL) daily, along with participation in a 6-week RT protocol. Muscular strength (1-repetition maximum [1RM] for hack squat [HS] and bench press [BP]), muscular endurance (repetitions to failure [RTF] for HS, leg extension [LE], BP, and incline press [IP]), rating of perceived exertion (RPE), and blood biomarkers (lactate, urea, and nitric oxide metabolites [NO]) were assessed before and after the intervention. This study was registered on irct.ir (IRCTID: IRCT20221128056642N1).

RESULTS

Comparing mean ∆ scores revealed a significant difference between LC and PL ( < 0.001) and between CM and PL ( = 0.026) for total upper body (the sum of BP and IP) RTF, but only a trend for difference between LC and PL ( = 0.070) for total lower body (the sum of HS and LE) RTF. A significant time effect for NO was detected only for LC ( = 0.014) and CM ( = 0.003). In addition, a significant difference between CM and PL ( = 0.009) and a marginally significant difference between LC and PL ( = 0.057) was detected regarding post-exercise NO values at post-intervention. There were no other between-group differences for any outcome measure.

CONCLUSION

Chronic citrulline supplementation seems to enhance upper body muscular endurance and post-exercise NO response to RT, but there is no apparent difference between LC and CM in these aspects.

摘要

目的

本研究旨在调查和比较长期补充L-瓜氨酸（LC）与L-瓜氨酸苹果酸（CM）对阻力训练（RT）表现的影响。

方法

33名进行阻力训练的男性被随机分配，每天摄入LC（8克）、CM（12克）或安慰剂（PL），同时参与一项为期6周的RT方案。在干预前后评估肌肉力量（哈克深蹲[HS]和卧推[BP]的1次重复最大值[1RM]）、肌肉耐力（HS、腿部伸展[LE]、BP和上斜卧推[IP]的重复至力竭次数[RTF]）、主观用力程度评级（RPE）和血液生物标志物（乳酸、尿素和一氧化氮代谢物[NO]）。本研究已在irct.ir上注册（IRCTID：IRCT20221128056642N1）。

结果

比较平均变化分数发现，对于上半身总体（BP和IP之和）RTF，LC与PL之间（<0.001）以及CM与PL之间（=0.026）存在显著差异，但对于下半身总体（HS和LE之和）RTF，LC与PL之间仅存在差异趋势（=0.070）。仅在LC组（=0.014）和CM组（=0.003）检测到NO有显著的时间效应。此外，在干预后，关于运动后NO值，CM与PL之间存在显著差异（=0.009），LC与PL之间存在边缘显著差异（=0.057）。对于任何结果指标，组间均无其他差异。