马凡综合征患者的口腔健康及与口腔健康相关的生活质量：一项横断面研究。

Oral health and oral health-related quality of life in people with Marfan syndrome: a cross-sectional study.

作者信息

Tetsch Nick Jan, Köppe Jeanette, Daume Linda, Kleinheinz Johannes, Hanisch Marcel, Oelerich Ole

机构信息

Department of Cranio- and Maxillofacial Surgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building W30, D-48151, Münster, Germany.

Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.

出版信息

BMC Oral Health. 2025 Jun 5;25(1):925. doi: 10.1186/s12903-025-06318-2.

DOI:10.1186/s12903-025-06318-2

PMID:40474214

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12143032/

Abstract

BACKGROUND

Marfan syndrome is a rare connective tissue disorder. This study was initiated to investigate the impact of Marfan syndrome on oral health.

METHODS

The person-reported perceived OHRQoL was determined using the German short version of the Oral Health Impact Profile (OHIP-G5). In addition, all study participants took part in a clinical examination in which the objective oral health was measured using the Physical Oral Health Index (PhOX).

RESULTS

A total of 29 patients took part in the study. Of these, 20 were female and nine male and the median age was 54 years (interquartile range (IQR): 15). The median OHIP-G5 score was three (IQR: 5) (range: 0-15). The median PhOX score was 79 (IQR: 14.5). A statistically significant correlation between the OHIP-G5 and the PhOX could not be determined (r=-0.34, p = 0.074).

CONCLUSIONS

The study showed that OHRQoL in particular was reduced. The measured oral health was slightly reduced compared to the general population. Nevertheless, Marfan patients should pay great attention to oral hygiene which should be checked by dental professionals at regular intervals.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

马凡综合征是一种罕见的结缔组织疾病。本研究旨在调查马凡综合征对口腔健康的影响。

方法

使用德国版简化口腔健康影响程度量表（OHIP-G5）确定个人报告的口腔健康相关生活质量（OHRQoL）。此外，所有研究参与者都参加了临床检查，使用口腔物理健康指数（PhOX）测量客观口腔健康状况。

结果

共有29名患者参与了该研究。其中，女性20名，男性9名，中位年龄为54岁（四分位间距（IQR）：15）。OHIP-G5评分的中位数为3（IQR：5）（范围：0-15）。PhOX评分的中位数为79（IQR：14.5）。无法确定OHIP-G5与PhOX之间存在统计学显著相关性（r = -0.34，p = 0.074）。