基因组的几何图形：构建三维基因组学的视觉语法

Geometric Diagrams of Genomes: constructing a visual grammar for 3D genomics.

作者信息

Molins-Pitarch Carla, Khao Jonathan, Bonet Santiago, Justicia Yolanda, Altube Clementina, Goodstadt Mike, Ribot Francesc, Aiden Erez Lieberman, Neretti Nicola, McGill Gaël G, Marti-Renom Marc A

机构信息

Image Processing and Multimedia Technology Center, Universitat Politècnica de Catalunya-Barcelona Tech, 08222, Terrassa, Spain.

Digizyme Inc, Brookline, MA, USA.

出版信息

Genome Biol. 2025 Jun 26;26(1):181. doi: 10.1186/s13059-025-03646-y.

DOI:10.1186/s13059-025-03646-y

PMID:40571947

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12203721/

Abstract

Advances in the field of three-dimensional (3D) genomics have revealed an ever-expanding array of architectural features that were unknown only a few years ago. Just as ribbon diagrams integrate spatial and symbolic representation to communicate the shape of a protein, the representation of genomes in 3D space requires the development and use of new cartographic symbols and visual conventions. Here, we propose a conceptualized grammar that makes it easier to create visual 3D representations of genomes.

摘要

三维（3D）基因组学领域的进展揭示了一系列不断扩展的结构特征，这些特征在几年前还不为人知。正如带状图整合空间和符号表示来传达蛋白质的形状一样，在三维空间中表示基因组需要开发和使用新的制图符号和视觉惯例。在这里，我们提出了一种概念化的语法，它使创建基因组的可视化三维表示变得更加容易。