Lakhal-Littleton Samira, Peyssonnaux Carole
Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France.
Adv Exp Med Biol. 2025;1480:89-102. doi: 10.1007/978-3-031-92033-2_7.
Hepcidin is primarily secreted by the liver and functions as an endocrine hormone. However, a growing number of studies show that hepcidin can also be produced locally by other cells and organs, where it acts in an autocrine/paracrine manner to mediate important iron-dependent pathways. These pathways can operate under normal homeostatic conditions or become relevant in pathophysiological conditions (inflammation, infection, cancer, liver disease, myocardial infarction, etc.). This chapter will delve into the local roles of hepcidin, highlighting its unconventional functions in barrier maintenance, host defense, growth, tissue housekeeping, and injury repair.
铁调素主要由肝脏分泌，作为一种内分泌激素发挥作用。然而，越来越多的研究表明，铁调素也可由其他细胞和器官在局部产生，在这些部位它以自分泌/旁分泌方式发挥作用，介导重要的铁依赖性途径。这些途径可在正常稳态条件下发挥作用，或在病理生理条件（炎症、感染、癌症、肝脏疾病、心肌梗死等）下变得重要。本章将深入探讨铁调素的局部作用，重点介绍其在屏障维持、宿主防御、生长、组织清理和损伤修复中的非常规功能。
