Hosomi Koji, Maruyama Satoko, Matsuoka Tsubasa, Furuta Mari, Tojima Yoko, Uchiyama Keita, Morita Makiko, Kawashima Hitoshi, Kobayashi Toshiki, Kunisawa Jun
Graduate School of Veterinary Science, Osaka Metropolitan University, 1-58 Rinku-Oraikita, Izumisano, Osaka, 598-8531, Japan.
Laboratory of Vaccine Materials, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan.
Microbiome. 2025 Jul 28;13(1):175. doi: 10.1186/s40168-025-02168-w.
BACKGROUND: The human gut harbors a diverse microbiota that is crucial for maintaining health but also contributes to several diseases. Understanding how microbial communities are assembled and maintained is critical for advancing gut health. RESULTS: We identified a unique interaction between the pathobiont Fusobacterium varium and the symbiont Faecalibacterium prausnitzii, both members of the gut microbial community; their interaction is driven by metabolites and direct cell-to-cell contact. Growth of F. varium was inhibited in the presence of F. prausnitzii because of a decrease in pH and an increase in β-hydroxybutyric acid. Conversely, the growth of F. prausnitzii was promoted in the presence of F. varium, likely via direct contact. CONCLUSIONS: These findings highlight the importance of metabolite-driven interactions and direct contact in shaping gut microbial communities and emphasize the potential of interactions between F. prausnitzii and F. varium in influencing gut health. Video Abstract.
背景：人类肠道中存在着多样化的微生物群，这对于维持健康至关重要，但也会引发多种疾病。了解微生物群落是如何组装和维持的，对于促进肠道健康至关重要。 结果：我们确定了肠道微生物群落中的致病共生菌变异梭杆菌（Fusobacterium varium）和共生菌普拉梭菌（Faecalibacterium prausnitzii）之间的独特相互作用；它们的相互作用由代谢产物和细胞间直接接触驱动。由于pH值降低和β-羟基丁酸增加，在普拉梭菌存在的情况下，变异梭杆菌的生长受到抑制。相反，在变异梭杆菌存在的情况下，普拉梭菌的生长可能通过直接接触得到促进。 结论：这些发现突出了代谢产物驱动的相互作用和直接接触在塑造肠道微生物群落中的重要性，并强调了普拉梭菌和变异梭杆菌之间的相互作用在影响肠道健康方面的潜力。视频摘要。
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