Kinetics of the distribution and elimination of chloroquine in the rat.

1. The distribution of chloroquine was studied in the tissues and blood of rat. 2. The time to peak concentration and the maximum concentration varied in various tissues and were higher than for plasma and red blood cells. 3. The tissue to plasma concentration ratio increased with time up to 144th hr for some tissues while this ratio was still increasing at the 168th hr for other tissues. 4. The values of beta estimated for the tissues were lower than those for plasma or red blood cells. The values differed from one another for the tissues but were similar for plasma and red blood cells.