渗透泵：优化给药方案的新型研究工具。

The osmotic pump: novel research tool for optimizing drug regimens.

作者信息

Eckenhoff B, Yum S I

出版信息

Biomaterials. 1981 Apr;2(2):89-97. doi: 10.1016/0142-9612(81)90005-3.

Abstract

Evaluation and selection of drugs, and determination of the optimal regimen, for controlled-release pharmaceutical products necessitate the reassessment of the pharmacology of drugs delivered at controlled rates. We have developed osmotic pumps for this purpose. These pumps, 1- and 2-week duration implants for animal studies, and 12- and 24-hour forms for oral and rectal administration in clinical studies, provide precise, accurate control over rate and duration of systemic or local drug delivery.

摘要

对于控释药物产品，药物的评估与选择以及最佳给药方案的确定需要重新评估以控速给药的药物的药理学特性。我们为此开发了渗透泵。这些泵有用于动物研究的1周和2周植入剂型，以及用于临床研究的口服和直肠给药的12小时和24小时剂型，可对全身或局部药物递送的速率和持续时间提供精确、准确的控制。