Pilc A, Nowak J Z
Pol J Pharmacol Pharm. 1980 Jul-Aug;32(4):469-73.
Intracerebroventricular injections of histamine in rats at ambient temperature of 32 degrees C induced a hyperthermic response, but depressed the body temperature at low and room temperatures. Agonists of H1 receptors caused hyperthermia at all ambient temperatures studied (9, 22 and 32 degrees C). The action of histamine and of H1 receptor agonists was inhibited by mepyramine and abolished by sodium salicylate. The involvement of both H1 receptors and prostaglandins in hyperthermia is suggested.
在32摄氏度的环境温度下，向大鼠脑室内注射组胺会引起体温升高反应，但在低温和室温下会降低体温。H1受体激动剂在所有研究的环境温度（9、22和32摄氏度）下都会引起体温升高。组胺和H1受体激动剂的作用被美吡拉敏抑制，并被水杨酸钠消除。提示H1受体和前列腺素都参与了体温升高过程。
