Kaidbey K H, Kligman A M
Contact Dermatitis. 1980 Apr;6(3):161-9. doi: 10.1111/j.1600-0536.1980.tb05590.x.
The photomaximization procedure was designed to identify topical photocontact sensitizers following the format of the maximization test for contact sensitizers. The test agent is applied for 24 hours followed by exposure to three Minimal Erythema Doses (MED) of solar simulated radiation twice weekly for 3 weeks (six exposures) in a panel of 25 white Caucasoids. The subjects are challenged 2 weeks later with 4.0 J/cm2 of long-wave ultraviolet radiation (UV-A). Photocontact sensitization was induced to 3,3'4',5-tetrachlorosalicylanilide (TCSA); dibromosalicylanilide (DBS) but not to tribomosalicylanilide unless the latter was contaminated with DBS. Jadit and bithionol were weak photoallergens. The highest rate of sensitization was given by 6-methylcoumarin, a widely used synthetic fragrance. Hexachlorophene and trichlorocarbanilide were negative.
光最大化程序旨在按照接触致敏剂最大化试验的形式来鉴定局部光接触致敏剂。在一组25名白种高加索人中，将受试物涂抹24小时，随后每周两次暴露于相当于三个最小红斑量（MED）的模拟太阳辐射下，持续3周（共6次暴露）。两周后，用4.0 J/cm² 的长波紫外线辐射（UV-A）对受试者进行激发试验。对3,3',4',5-四氯水杨酰苯胺（TCSA）、二溴水杨酰苯胺（DBS）可诱导光接触致敏，但对三溴水杨酰苯胺则不能，除非后者被DBS污染。贾迪特和硫双二氯酚是弱光变应原。致敏率最高的是6-甲基香豆素，一种广泛使用的合成香料。六氯酚和三氯卡班呈阴性。
