Shiga C, Shiga K, Hirayama K, Katayama M, Nishihira T, Mori S
Department of Surgery II, Tohoku University School of Medicine, Sendai, Japan.
Anticancer Res. 1994 Mar-Apr;14(2B):651-6.
We studied hst-1 gene amplification in 50 primary human esophageal carcinomas using Southern blot analysis. We found 3- to 9-fold amplification of the hst-1 gene in 15 out of 50 (30.0%) DNA samples from primary tumors. There was no evidence of a correlation between hst-1 gene amplification and several prognostic factors other than the histological type; hst-1 gene amplification was more common in well differentiated squamous cell carcinoma. Survival rates for patients bearing tumors with and without hst-1 gene amplification were calculated by the Kaplan-Meier method and evaluated by the log-rank test. The survival curves for the two groups were almost identical. These results suggest that amplification of the hst-1 gene is a poor indicator of the prognosis of patients who have undergone surgery for primary esophageal carcinoma.
我们使用Southern印迹分析法研究了50例原发性人类食管癌中的hst-1基因扩增情况。我们在50份原发性肿瘤的DNA样本中有15份（30.0%）发现hst-1基因有3至9倍的扩增。除了组织学类型外，没有证据表明hst-1基因扩增与其他几个预后因素之间存在相关性；hst-1基因扩增在高分化鳞状细胞癌中更为常见。采用Kaplan-Meier法计算有和没有hst-1基因扩增的肿瘤患者的生存率，并通过对数秩检验进行评估。两组的生存曲线几乎相同。这些结果表明，hst-1基因扩增对于接受原发性食管癌手术的患者来说，是一个预后不良的指标。
