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[肺高频通气对肺循环和体循环的影响]

[The effect of high-frequency ventilation of the lungs on the pulmonary and systemic circulations].

作者信息

Sanotskaia N V, Vyzhigina M A, Matsievskiĭ D D, Luk'ianov M V, Aleĭnikov S O

出版信息

Biull Eksp Biol Med. 1993 Sep;116(9):239-41.

PMID:8117987
Abstract

By means of ultrasonic method used in acute experiments on cats with open chest under nembutal narcosis the authors studied the linear and volumetric blood flow velocity in the ascending aorta and conus of the pulmonary artery, the balance between the cardiac output of right and left ventricles, as well as blood pressure (BP) in pulmonary and femoral arteries, the pulmonary microvascular bed under conversion from traditional to the high frequency jet ventilation (HFJV). It was shown that under HFJV there were decreases in pulmonary BP and pulmonary vascular resistance, a reduction of right ventricular output, redistribution of blood to the general circulation. At the same time, in most experiments the linear blood velocity in the aorta and in the pulmonary artery, systemic BP, the general vessel resistance remained stable. HFJV, unlike conventional artificial lung ventilation did not cause any deformation of the pulmonary microvascular bed. There was an insignificant decrease of the capillary perfusion index. The change of such parameters as cardiac output, stroke volume, stroke index, cardiac in index in the central circulatory hemodynamics occurred 5 minutes following the same and unidirectional changes in the lesser circulation. The stabilisation of fundamental hemodynamic parameters took place from 10 to 20 minutes after conversion to HFJV.

摘要

作者在戊巴比妥麻醉下对开胸猫进行急性实验,通过超声法研究了升主动脉和肺动脉圆锥处的线性和容积血流速度、左右心室心输出量的平衡以及肺和股动脉血压(BP),以及从传统通气转换为高频喷射通气(HFJV)时的肺微血管床情况。结果表明,在HFJV下,肺血压和肺血管阻力降低,右心室输出量减少,血液重新分配至体循环。同时,在大多数实验中,主动脉和肺动脉中的线性血流速度、体循环血压、总血管阻力保持稳定。与传统人工肺通气不同,HFJV不会导致肺微血管床出现任何变形。毛细血管灌注指数有轻微下降。在小循环中相同且单向变化5分钟后,中心循环血流动力学中的诸如心输出量、每搏输出量、每搏指数、心脏指数等参数发生变化。转换为HFJV后10至20分钟,基本血流动力学参数趋于稳定。

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