Deitmer P, Golenhofen K, Noack T
Department of Physiology, University of Marburg, Lahn, Federal Republic of Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Oct;348(4):411-6. doi: 10.1007/BF00171341.
The inhibitory effect of cicletanine was studied, in comparison to the effects of nifedipine and sodium nitroprusside (SNP), in various types of smooth muscle: portal vein and iliac artery of rabbit; gastric fundus and antrum of rabbit and guinea pig; guinea pig taenia coli and uterus. In all types of tissue the nifedipine-sensitive component (LCA, L-type calcium channel dependent activation) was inhibited by cicletanine (threshold concentration 10(-6) mol/l to 10(-5) mol/l). The nifedipine to resistant component (NLCA) was in some tissues preferentially inhibited by SNP (gastric fundus) and in other tissues preferentially by cicletanine (portal vein), with graded intermediate forms (iliac artery). Consequently, the inhibitory effect of cicletanine on NLCA is different in mechanism to that of SNP. Only papaverine suppressed all types of activation.
与硝苯地平和硝普钠（SNP）的作用相比，研究了西氯他宁对各种类型平滑肌的抑制作用：兔的门静脉和髂动脉；兔和豚鼠的胃底和胃窦；豚鼠的结肠带和子宫。在所有类型的组织中，西氯他宁抑制硝苯地平敏感成分（LCA，L型钙通道依赖性激活）（阈浓度为10^(-6)mol/L至10^(-5)mol/L）。硝苯地平耐药成分（NLCA）在某些组织中优先被SNP抑制（胃底），而在其他组织中优先被西氯他宁抑制（门静脉），还有分级的中间形式（髂动脉）。因此，西氯他宁对NLCA的抑制作用机制与SNP不同。只有罂粟碱能抑制所有类型的激活。
